1621

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September 29: The First Thanksgiving the New World as imagined by Jennie A. Brownscombe in 1914

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The Siege of Montauban.

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Events

January–March

January 12 – Şehzade Mehmed, the 15-year old half-brother of Ottoman Sultan Osman II, is put to death by hanging on Osman's orders. Before dying, Mehmed prays aloud that Osman's reign as Sultan be ruined.
January 18 – The Dutch East India Company formally names its fortress at Jayakarta in Indonesia, calling it Batavia. Upon the independence of the Dutch East Indies as Indonesia in 1945, Batavia will be renamed Jakarta.
January 22 – The Tianqi era begins in Ming Dynasty China, six months after Zhu Changluo becomes the Taichang Emperor.
January 24 – Twelve days after the murder of Prince Mehmed on orders of Sultan Osman II, Constantinople is hit by bitter winter weather, leading to rioting by persons who believe that the punishment of Osman is the will of Allah.
January 28 – Pope Paul V (Camillo Borghese) dies at the age of 70 after 15 years as Pontiff.
January 29 – Ferdinand II, Holy Roman Emperor, declares the Elector of the Palatinate, Frederick V, to be a traitor to the Empire.
February 9 – Papal Conclave of 1621: Pope Gregory XV succeeds Pope Paul V, as the 234th pope.
February 17 – Myles Standish is appointed as the first commander of Plymouth Colony.<ref>Template:Cite book</ref>
March 16 – Samoset, a Mohegan, visits the settlers of Plymouth Colony and greets them: "Welcome, Englishmen! My name is Samoset."
March 22 – The Pilgrims of Plymouth Colony sign a peace treaty with Massasoit of the Wampanoags.
March 31 – King Philip IV of Spain begins his 44-year rule.<ref>Template:Cite book</ref>

April–June

April 1 – The Plymouth, Massachusetts colonists create the first treaty with native Americans.
April 5 – The Mayflower sets sail from Plymouth, on a return trip to England.
April 9 – The Twelve Years' Truce between the Dutch Republic and the Spanish Empire expires, and both sides prepare to resume the Eighty Years' War.
May 2 – The Panama earthquake affects the Isthmus of Panama, with an estimated magnitude of 6.9, and a maximum Mercalli intensity of VII.
May 12 – The city of Tornio in Lapland is founded by King Gustavus Adolphus of Sweden, becoming the northernmost city in the world at the time.<ref>Template:Cite web</ref>
May 24 – The Protestant Union is formally dissolved.
June 3 – The Dutch West India Company is founded.<ref>Template:Cite book</ref>
June 21 – Thirty Years' War: Twenty-seven Czech lords are executed on the Old Town Square in Prague, as a consequence of the Battle of White Mountain.
June 24 – Huguenot rebellions: Saint-Jean-d'Angély is taken, after a 26-day siege by Royal forces.

July–September

July 25 – Thirty Years' War – Battle of Neu Titschein: Remnants of the Bohemian army temporarily hold off the Imperial advance in Silesia.
August 8 – Huguenot rebellions: The French Protestant city of La Rochelle joins in the revolt by Benjamin, Duke of Soubise.
August 22 – Huguenot rebellions: Louis XIII of France besieges the city of Montauban, but is forced to abandon the battle by November 9.
September 2 – The Battle of Khotyn begins as a force of more than 120,000 Ottoman troops attacks the Moldavian city of Khotyn. Despite the Ottomans' numerical superiority, the Polish-Lithuanian Commonwealth wins the battle and forces a surrender five weeks later. <ref name="Żółkiewski1959">Template:Cite book</ref>

October–December

October 9 – The Treaty of Khotyn is signed between the Ottoman Empire and the Polish–Lithuanian Commonwealth, ending the First Polish-Ottoman War.<ref name="Żółkiewski1959"/>
October 9 (September 29 O.S.) – The Pilgrims of Plymouth Colony and Wampanoags celebrate a harvest feast (three days), later regarded as the First Thanksgiving, noted for the temporary peace between the English and the local Indians. The celebration is believed by later historians to have coincided with Michaelmas, observed on September 29 by the Anglican Communion on the calendar used in England at the time.
November 11 – The ship Fortune arrives at Plymouth Colony, with 35 more settlers.
December 31 – Thirty Years' War: The Peace of Nikolsburg is signed between Ferdinand II, Holy Roman Emperor and Gabor Bethlen, Prince of Transylvania. Bethlen agrees to renounce his claims to Hungary. In return Bethlen receives several counties and lands along the eastern border of the Holy Roman Empire, and Moravia is granted religious freedom.
December – The Dutch mathematician and astronomer, Willebrord Snel van Royen (1580–1626), reveals he has rediscovered the law of refraction, also known as Snellius' law.<ref name="Sarton1936">Template:Cite book</ref>

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The Venezuelan city of Petare is founded by Spanish conquistadors, as San Jose de Guanarito.
The Swedish city of Gothenburg is founded by King Gustavus Adolphus of Sweden.<ref>Template:Cite book</ref> The king also grants city rights to Luleå, Piteå and Torneå (Tornio). Riga falls under the rule of Sweden.
Tamblot rallies an unknown, large number of people in Bohol, Captaincy General of the Philippines to revolt against the Spanish Empire.<ref>Template:Cite book</ref>
The Dutch East India Company sends 2,000 soldiers, under the command of Jan Pieterszoon Coen, to the Banda Islands, in order to force the local inhabitants to accept the Dutch trade monopoly on the lucrative nutmeg, grown almost exclusively on those islands. The soldiers proceed to massacre most of the 15,000 indigenous inhabitants.