January 12 (10th waxing of Tabodwe 915 ME) – Bayinnaung is crowned king of the Burmese Taungoo Dynasty at his new capital at Pegu, after a previous coronation on January 11, 1551, and takes the regnal name of Thiri Thudhamma Yaza.<ref>Template:Cite book</ref>
January 27 – Wyatt's rebellion begins in England at Maidstone as Sir Thomas Wyatt reads a proclamation that Queen Mary of England’s marriage to King Philip of Spain will "bring upon this realm most miserable servitude, and establish popish religion". Within two days, Wyatt has raised 2,000 soldiers to join his plan to overthrow Queen Mary.<ref>Template:Cite book</ref>
May 9 – Elizabeth is released from the Tower of London, although she continues to be confined at home after she is cleared of suspicion of conspiracy to overthrow the government.
September 13 (Shawwal 15, 961 AH) – At the Battle of Tadla in Morocco, Mohammed ash-Sheikh, ruler of the Saadi dynasty enters the city of Fez and becomes the undisputed sultan. Ali Abu Hassun, last ruler of the Wattasid dynasty, flees.<ref>Jamil Marhi and Abu Al-Nasr, History of Morocco in the Islamic Era (Cambridge University Press, 1987) p.155</ref>
October 8 – In Peru, an 11-month long rebellion by Francisco Hernández Girón is ended at the Battle of Pucará with the rebels defeated by the Viceroy of Peru near Cuzco.<ref>Severo Martinez Pelaez, La patria del criollo: ensayo de interpretación de la realidad colonial guatemalteca (Fondo de Cultura Económica, 2013)</ref><ref>Template:Cite book</ref>
November 1 – English captain John Lok, commanding three ships (the Trinitie, the Bartholomew and the John Evangelist), departs from Dartmouth in England to voyage to the Guinea Coast at West Africa.<ref name=Hakluyt>Richard Hakluyt, The Principal Navigations, Voyages, Traffiques & Discoveries of the English Nation Made by Sea Or Overland to the Remote and Farthest Distant Quarters of the Earth at Any Time Within the Compass of These 1600 Years (1597, reprinted by J. M. Dent and Sons, Ltd., 1927) pp.47-50 ("The first day of November at nine of the clocke at night, departing from the coast of England, se set off...")</ref><ref name=tts245>Template:Cite book</ref><ref>Template:Cite book</ref>
December 22 – The John Lok expedition reaches Guinea, anchoring at the Sesto River and remains for seven days to begin trading.<ref name=Hakluyt/>"<ref>p.50 ("The two and twentieth of December we came to the river of Sesto & remained there until the nine and twentieth day of said moneth.")</ref>
The name of the beer brewed by New Belgium Brewing Company is based on a recipe from this date, called "1554."
Luso-Chinese agreement: Portugal reaches an agreement with the Ming Dynasty of China, to be allowed to legally trade in the province of Guangdong. This agreement is often seen as a starting point of the Portuguese colony of Macau