Oxford and Lafayette County were formed from lands ceded by the Chickasaw people in the Treaty of Pontotoc Creek in 1832. The county was organized in 1836, and in 1837 three pioneers—John Martin, John Chisom, and John Craig—purchased land from Hoka, a female Chickasaw landowner, as a site for the town.<ref>Jack Lamar Mayfield. Oxford and Ole Miss. Arcadia Publishing, 2009, p. 7.</ref> They named it "Oxford", intending to promote it as a center of learning in the Old Southwest.<ref>Template:Cite web</ref> In 1841, the Mississippi legislature selected Oxford as the site of the state university, which opened in 1848.
During this period many African American freedmen moved from farms into town and established a neighborhood known as "Freedmen Town", where they built houses, businesses, churches and schools, and exercised all the rights of U.S. citizenship.<ref>Template:Cite web</ref> Even after Mississippi disenfranchised most African Americans in the 1890 Constitution of Mississippi, they continued to build their lives in the face of discrimination.
During the Civil Rights Movement, Oxford drew national attention in the Ole Miss riot of 1962. State officials, including Governor Ross Barnett, prevented James Meredith, an African American, from enrolling at the University of Mississippi, even after the federal courts had ruled that he be admitted. Following secret face-saving negotiations with Barnett, President John F. Kennedy ordered 127 U.S. Marshals, 316 deputized U.S. Border Patrol agents and 97 federalized Federal Bureau of Prisons officers to accompany Meredith.<ref>Template:Cite web</ref> Thousands of armed "volunteers" flowed into the Oxford area. Meredith traveled to Oxford under armed guard to register, but riots by segregationists broke out in protest of his admittance.
That night, cars were burned, federal law enforcement were pelted with rocks, bricks and small arms fire, and university property was damaged by 3,000 rioters. Two civilians were killed by gunshot wounds, and the riot spread into adjacent areas of the city of Oxford.<ref>Doyle, William. An American Insurrection: James Meredith and the Battle of Oxford, Mississippi, 1962. New York: Anchor Books, 2003.</ref> Order was finally restored to the campus with the early morning arrival of 3,000 nationalized Mississippi National Guard and federal troops, who camped in the city.<ref>Template:Cite web</ref>
The city is located in the North Central Hills region of Mississippi. The region is known for its heavily forested hills made up of red clay. The area is higher and greater in relief than areas to the west (such as the Mississippi Delta or loess bluffs along the Delta), but lower in elevation than areas in northeast Mississippi. The changes in elevation can be noticed when traveling on the Highway 6 bypass, since the east-west highway tends to transect many of the north-south ridges. Downtown Oxford sits on one of these ridges and the University of Mississippi sits on another one, while the main commercial corridors on either side of the city sit in valleys.
The streets in the downtown area follow a grid pattern with two naming conventions. Many of the north-south streets are numbered from west to east, beginning at the old railroad depot, with numbers from four to nineteen. The place of "Twelfth Street", however, is taken by North and South Lamar Boulevard (formerly North Street and South Street). The east-west avenues are named for the U.S. presidents in chronological order from north to south, from Washington to Cleveland; here again, there are gaps: there is no street for John Quincy Adams, who shares a last name with John Adams; "Polk Avenue" is replaced by University Avenue; and "Arthur Avenue" is lacking.
As of the census<ref name="GR2">Template:Cite web</ref> of 2010, there were 18,916 people, with 8,648 households residing in the city. The racial makeup of the city was 72.3% White, 21.8% African American, 0.3% Native American, 3.3% Asian, 0.1% Pacific Islander, and 1.1% from two or more races. Hispanic or Latino people of any race were 2.5% of the population. The average household size was 2.09.
The median income for a household in the city was $38,872, and the average household income was $64,643. The per capita income for the city was $29,195.<ref>Oxford, MS Household Income Statistics. CLRSearch. Retrieved on August 17, 2013. Template:Dead link</ref> About 12% of families and 32.3% of the population were below the poverty line.
In addition to the historic Lafayette County Courthouse, the Square is known for an abundance of locally owned restaurants, specialty boutiques, and professional offices, along with Oxford City Hall.
The J. E. Neilson Co., located on the southeast corner of the Square, is the South's oldest documented store. Founded as a trading post in 1839, Neilson's continues to anchor the Oxford square. Neilsons (pronounced Nelsons) was one of the few stores to survive the burning of Oxford during the Civil war. It stands within eyesight of one of Oxford's two confederate statues (one was erected after the original faced south because the South "never retreats;" a Falkner (William added a "U") paid for the second). Neilson's also features a letter from William Faulkner, who repeatedly refused to pay debts owed to the department store. When the Great Depression hit Oxford and most of the banks in town closed, Neilson's acted as a surrogate bank, cashing paychecks for university employees and others. Neilson's is also the only store in Oxford to carry supplies for Boy Scout uniforms.
Square Books, founded in 1979, is an independent bookstore.<ref>Template:Cite news</ref> A sister store, Off Square Books, is several doors down the street to the east. It deals in used and remainder books and is the venue for a radio show called Thacker Mountain Radio, with host Jim Dees, that is broadcast statewide on Mississippi Public Broadcasting. The show often draws comparisons to Garrison Keillor's A Prairie Home Companion for its mix of author readings and musical guests. A third store, Square Books Jr., deals exclusively in children's books and educational toys.
The Lyric Theater, just off the courthouse square, is Oxford's largest music venue, with a capacity near 1200. Originally built in the late 1800s, the structure became a livery stable owned by William Faulkner's family in the early part of the 20th century. During the 1920s it became Oxford's first motion picture theater, the Lyric. In 1949, Faulkner walked from his home in Oxford to his childhood stable for the world premiere of MGM's Intruder in the Dust, adapted from one of his novels. The building housed office space and a health center from the early 1980s. After extensive restoration, the Lyric reopened on July 3, 2008, as a live music venue. It also is used occasionally for film and live drama.
The Gertrude Castellow Ford Center for the Performing Arts on the University of Mississippi's campus hosts a broad range of events, such as symphony performances, operas, musicals, plays, comedy tours, chamber music, and guest lectures. The Ford Center, as it is commonly known, also hosted the 2008 presidential debate between former President Barack Obama and Senator John McCain.
The University of Mississippi Museum is located on the University of Mississippi's main campus. The Robinson collection of Greek and Roman antiquities and the Millington-Barnard collection of 19th century scientific instruments are permanent collections of the museum. The museum is also home to the personal collections of Kate Skipwith and Mary Buie. The permanent exhibits are free to the public.<ref>Template:Cite web</ref>
The Burns-Belfry Museum was previously the Burns Methodist Episcopal Church organized by freed African Americans in 1910. Now, the museum pays tribute to its role in the Civil War era. The museum houses a permanent exhibit on African American history that spans from slavery through the Civil Rights Movement.<ref>Template:Cite web</ref>
Bob Dylan wrote a song called "Oxford Town", which was included on his 1963 album The Freewheelin' Bob Dylan. The song was about the violent events surrounding the admission of James Meredith into the University of Mississippi in 1962. Dylan played a memorable concert at the Tad Smith Coliseum on the Ole Miss campus in November 1990, which opened with a performance of the song "Oxford Town".
The Baptist Memorial Hospital - North Mississippi, located in Oxford provides comprehensive health care services for Oxford and the surrounding area, supported by a growing number of physicians, clinics and support facilities. The North Mississippi Regional Center, a state-licensed Intermediate Care Facility for Individuals with Intellectual Disabilities (ICF/IID), is located in Oxford.
Oxford is home to the National Center for Natural Products Research at the University of Mississippi's School of Pharmacy. The Center is the only facility in the United States that is federally licensed to cultivate marijuana for scientific research, and to distribute it to medical marijuana patients.
The city operates public transportation under the name Oxford-University Transit (OUT), with bus routes throughout the city and University of Mississippi campus.<ref>Template:Cite web</ref> Ole Miss students and faculty ride free upon showing University identification.
University-Oxford Airport is a public use airport located two nautical miles (4 km) northwest of the central business district of Oxford. The airport is owned by the University of Mississippi.
Secretary of the InteriorJacob Thompson (1810–1885) owned a manor called "Home Place" in Oxford that was burned during the Civil War by Union troops. A historical marker stands where it once stood.
L.Q.C. Lamar (1825–1893), U.S. senator and supreme court justice, resided in Oxford, where he served as professor of mathematics at the University of Mississippi, farmed, and practiced law. He was the son-in-law of university chancellor Augustus Baldwin Longstreet. Lamar's home in Oxford was restored as a museum in 2008.
Angela McGlowan (born 1970), Republican political commentator, author, and consulting firm CEO
Naomi Sims (1948–2009), fashion model, was born in Oxford.