1506

April 19: Lisbon Massacre kills thousands of Jews in Portugal over three days.

January 22: Swiss Guard arrives to protect the Vatican, remains unchanged 500 years later.

Events

January 14 – The classical statue of Laocoön and His Sons is unearthed in Rome. On the recommendation of Giuliano da Sangallo and Michelangelo, Pope Julius II purchases it, and places it on public display in the Vatican a month later.
January 22 – The Swiss Guard arrives at the Vatican, to serve as permanent ceremonial and palace guards under Pope Julius II.
February 9 – Henry, Prince of Wales is made a Knight of the Golden Fleece by Maximilian I, Holy Roman Emperor.
February 15 – Iye Roy Mackay, Chief of Scotland's Clan Mackay, records his 1504 grant of six lands in what is now the County Sutherland, and starts a feud with Euphemia II, Countess of Ross.
March 16 – Battle of Cannanore: Portugal's fleet (commanded by Lourenço de Almeida) defeats the fleet of the Zamorin of Calicut, with hundreds of vessels involved; 3,000 Muslim troops are killed.
March 30 – King Vladislaus II of Hungary and Maximilian I, Holy Roman Emperor sign a treaty to arrange the marriage of Vladislaus's daughter and Maximilian's son.

April 18 – Pope Julius II lays the foundation stone of the new (current) St. Peter's Basilica in Rome, replacing the Old St. Peter's Basilica.
April 19 – The Lisbon Massacre begins in Portugal with three days of violence, in which thousands of Jews are tortured and killed by Catholics.
April 30 – Malus Intercursus, a treaty between King Henry VII of England and Duke Philip IV of Burgundy, is signed.
May 4 – Badi' al-Zaman Mirza becomes the new Emir of the Timurid Empire (now part of Afghanistan) after the death of his father, Sultan Husayn Bayqara, who died after a reign of 37 years.
May 28 – Emperor Moctezuma II of Mexico's Aztec Empire subdues a rebellion in Zozollan, east of Achiutia, then kills the prisoners of war as a sacrifice to the gods.
June 15 – Mahmud Shah II begins a 41-year reign as the Sultan of Kedah, a Muslim kingdom on the Malay Peninsula, on the death of his father, Adilin I.
June 27 – The Treaty of Villafáfila is signed between Austria and Spain.

July 12 – Philip the Fair, Duke of Burgundy, becomes the ruler of the Spanish Kingdom of Castile with his insane wife Joanna, but reigns for only two months before dying of typhoid.
August 6 – Battle of Kletsk: The Grand Duchy of Lithuania defeats the Tatars of the Crimean Khanate.
August 19 – Sigismund I the Old succeeds his brother as king of Poland.<ref>Template:Cite web</ref>
September 2 – In Korea, Emperor Yonsangun, known for being a tyrant, is deposed in the Jungjong coup by his younger brother, who becomes King Jungjong.
September 25 – Philip I, the first Spanish Habsburg King of Castile, dies suddenly from typhoid.

October 6 – In Córdoba, in the Spanish kingdom of Andalusia, members of the nobility and the general public revolt against the Spanish inquisitor Diego Rodriguez de Lucero and General Inquisitor Diego de Deza. The mob liberates the people incarcerated at the Córdoba prison.
October 7 – Pope Julius II issues a bull excommunicating Giovanni II Bentivoglio from the Roman Catholic Church, who had dominated the Italian city state of Bologna.
October 15 – Charles II, the six-year-old son of King Philip of Castile, inherits his father's title of Duke of Burgundy and is proclaimed "Lord of the Netherlands".
November 6 – Pope Julius II personally leads his troops into Bologna, retaking the city from the excommunicated tyrant Giovanni II Bentivoglio.
December 8 – Sigismund I the Old (Zygmunt Jagiellon), younger brother of the late Alexander Jagiellon, becomes the King of Poland and (as Zygimantas II) the Grand Duke of Lithuania. He will reign for more than 40 years, dying in 1548 at the age of 81.

The Portuguese mariner Tristão da Cunha sights the islands of Tristan da Cunha, naming them after himself.
In Ming dynasty China, the costs of the courier system are met by a tax in silver on land, instead of corvée labor service.
Duarte Barbosa returns to Lisbon.
Johannes Trithemius becomes abbot of the monastery of St. Jacob, at Würzburg.
Leonardo da Vinci completes most of his work on the Mona Lisa.