Hydroxylysine
Hydroxylysine (Hyl) is an amino acid with the molecular formula C6H14N2O3. It was first discovered in 1921 by Donald Van Slyke as the 5-hydroxylysine form.<ref>Template:Cite journal</ref> It arises from a post-translational hydroxy modification of lysine. It is most widely known as a component of collagen.<ref>Hydroxylysine at University of Oulu</ref>
It is biosynthesized from lysine via oxidation by lysyl hydroxylase enzymes. The most common form is the (5R) stereoisomer found in collagen. However, the enzyme JMJD6 has recently been shown to be a lysyl hydroxylase which modifies an RNA splicing factor producing the (5S) stereoisomer. Additionally, in E. coli, there has been at least one lysine N-hydroxylase enzyme identified, named IucD.<ref>Template:Cite journal</ref>
References
[edit]<references/>