DRM

Government, military and politics

Defense reform movement, U.S. campaign inspired by Col. John Boyd
Democratic Republic of Madagascar, a former socialist state (1975–1992) on Madagascar
Direction du renseignement militaire, the French Directorate of Military Intelligence
Disability rights movement
Disaster risk management

Digital rights management, access control technologies that limit the usage of digital content and devices
- "Digital restrictions management", a re-purposing of the acronym by the Defective by Design movement
Data Reference Model, one of the five reference models of the Federal Enterprise Architecture
Digital Radio Mondiale, a set of digital audio broadcasting technologies
Direct Rendering Manager, a component of Linux's Direct Rendering Infrastructure
Distributed resource manager or job scheduler, a software application that is in charge of unattended background executions

Deese–Roediger–McDermott paradigm, a paradigm in cognitive psychology for investigating false memories
Desmin related myopathy, a subgroup of the myofibrillar myopathy diseases
Detergent resistant membrane, a lipid raft
Digestive rate model, the diet selection that animals should perform to maximize energy or nutrients
Gremlin (protein) or Drm, an inhibitor in the TGF beta signaling pathway

Danbury Railway Museum, Connecticut, US
DRM (Japanese band), a J-pop girl group
Dispute resolution mechanism, an acronym applicable to dispute resolution (e.g., in diplomatic or contractual matters)
Di Ravello Militia, the main antagonist faction in Just Cause 3