Congenital rubella syndrome

Congenital rubella syndrome (CRS) occurs when a human fetus is infected with the rubella virus (German measles) via maternal-fetal transmission and develops birth defects.<ref name=Vesikari2021>Template:Cite book</ref> The most common congenital defects affect the ophthalmologic, cardiac, auditory, and neurologic systems.<ref name=Jong2022>Template:Cite book</ref>

Rubella infection in pregnancy can result in various outcomes ranging from asymptomatic infection to congenital defects to miscarriage and fetal death.<ref name=":12">Template:Cite journal</ref><ref name=":2">Template:Cite web</ref> If infection occurs 0–11 weeks after conception, the infant has a 90% risk of being affected.<ref name=Vesikari2021/> If the infection occurs 12–20 weeks after conception, the risk is 20%. Infants are not generally affected if rubella is contracted during the third trimester.<ref name=":12" /> Diagnosis of congenital rubella syndrome is made through a series of clinical and laboratory findings and management is based on the infant's clinical presentation. Maintaining rubella outbreak control via vaccination is essential in preventing congenital rubella infection and congenital rubella syndrome.<ref name=":12" />

Congenital rubella syndrome was discovered in 1941 by Australian Norman McAlister Gregg.<ref name="CDC2012Pink2">Template:Cite book</ref>

Signs and symptoms

File:Infant with skin lesions from congenital rubella.jpg

Infant with skin lesions from congenital rubella

File:Congenital Rubella Syndrome, Salt and Pepper Retinopathy.jpg

"Salt-and-pepper" retinopathy is characteristic of congenital rubella.<ref name=Sudharshan>Template:Cite journal</ref><ref>Template:Cite journal</ref>

The classic triad for congenital rubella syndrome is:<ref>Template:Cite web</ref>

• Sensorineural deafness<ref name=":52">Template:Cite book</ref> (58% of patients)<ref name=":13">Template:Cite web</ref>
• Eye abnormalities—especially retinopathy,<ref name=":52" /><ref name=":32">Template:Cite journal</ref> cataract,<ref name=":13" /><ref name=":32" /> glaucoma,<ref name=":32" /> and microphthalmia<ref>Template:Cite journal</ref> (43% of patients)<ref>Template:Cite journal</ref>
• Congenital heart disease<ref name=":22">Template:Citation</ref>—especially pulmonary artery stenosis and patent ductus arteriosus (50% of patients)<ref>Template:Cite journal</ref>

Other manifestations of CRS may include:

• Spleen,<ref name=":52" /><ref name=":32" /> liver, or bone marrow problems (some of which may disappear shortly after birth)
• Intellectual disability<ref>Template:Cite journal</ref>
• Small head size (microcephaly)<ref name=":32" />
• Low birth weight<ref name=":0">Template:Cite web</ref>
• Thrombocytopenic purpura,<ref name=":52" /><ref name=":1">Template:Cite journal</ref> leading to easy or excessive bleeding or bruising
• Extramedullary hematopoiesis (presents as a characteristic blueberry muffin rash)<ref name=Jong2022/>
• Enlarged liver (hepatomegaly)<ref name=":5" />
• Small jaw size (micrognathia)<ref name=":1" />
• Radiolucent bone disease<ref name=":32" />
• Skin lesions <ref name=":0" />

Children who have been exposed to rubella in the womb should also be watched closely as they age for any indication of:

• Developmental delay<ref name=":0" />
• Autism<ref name=":22" /><ref name=":1" /><ref name="pmid15121991">Template:Cite journal</ref>
• Schizophrenia<ref name="pmid16469941">Template:Cite journal</ref>
• Growth retardation<ref>Template:Cite journal</ref>
• Learning disabilities<ref name=":1" />
• Thyroid disorders<ref name=":1" /><ref name=":4">Template:Cite journal</ref>
• Diabetes mellitus<ref name=":4" /><ref>Template:Cite journal</ref>

Diagnosis

File:Rubella serology.png

Congenital rubella serology timeline

Diagnosis of congenital rubella syndrome is made based on clinical findings and laboratory criteria.<ref name=":12" /> Laboratory criteria includes at least one of the following:

• Detection of the rubella virus via RT-PCR<ref name=":5" />
• Detection of rubella-specific IgM antibody<ref name=":5" />
• Detection of infant rubella-specific IgG antibody<ref name=":5" /> at higher levels (and persists for a longer time) than expected for passive maternal transmission
• Isolation of the rubella virus by nasal, blood, throat, urine, or cerebrospinal fluid specimens

Clinical definition is characterized by findings in the following categories:

1. Cataracts/congenital glaucoma, congenital heart disease (most commonly, patent ductus arteriosus or peripheral pulmonary artery stenosis), hearing impairment, pigmentary retinopathy
2. Purpura, hepatosplenomegaly, jaundice, microcephaly, developmental delay, meningoencephalitis, radiolucent bone disease

A patient is classified into the following cases depending on their clinical and laboratory findings:<ref name=":12" />

• Suspected: A patient that has one or more of the clinical findings listed above but does not meet the definition for probable or confirmed classification
• Probable: A patient that does not have laboratory confirmation of congenital rubella but has either two clinical findings from Group 1 as listed above OR one clinical finding from Group 1 and one clinical finding from Group 2 as listed above
• Confirmed: A patient with at least one laboratory finding and one clinical finding (from either group) as listed above
• Infection only: A patient with no clinical findings as described above but meeting at least one confirmed laboratory criteria

Prevention

Vaccinating the majority of the population is effective at preventing congenital rubella syndrome.<ref name=WHO2011>Template:Cite journal</ref> With the introduction of the rubella vaccine in 1969, the number of cases of rubella in the United States has decreased 99%, from 57,686 cases in 1969 to 271 cases in 1999.<ref name=":12" /> For women who plan to become pregnant, the MMR (measles mumps, rubella) vaccination is highly recommended, at least 28 days prior to conception.<ref name=":0" /> The vaccine should not be given to women who are already pregnant as it contains live viral particles.<ref name=":0" /> Other preventative actions can include the screening and vaccinations of high-risk personnel, such as medical and child care professions.<ref>Template:Cite web</ref>

Infants with birth defects suspected to be caused by congenital rubella infection should be investigated thoroughly. Confirmed cases should be reported to the local or state health department to assess control of the virus and isolation of the infant should be maintained.<ref name=":3">Template:Citation</ref>

Management

Infants with known rubella exposure during pregnancy or those with a confirmed or suspected infection should receive close follow-up and supportive care. There are no medications or antivirals that will shorten the clinical course of the virus.<ref name=":2" /> Only those with immunity to rubella should have contact with infected infants, as they can shed viral particles in their respiratory secretions though 1 year of age (unless they test with repeated negative viral cultures at age 3 months).<ref name=":12" /> Many infants can be born with multiple birth defects that require multidisciplinary management and interventions based on clinical manifestations. Often these infants will require extended period or life-long follow up with medical specialists. Early diagnosis of congenital rubella syndrome is important for planning future medical care and educational placement.<ref name=":5">Template:Cite journal</ref>

Auditory Care

Many infants with CRS may be born with sensorineural deafness and thus should undergo a newborn hearing evaluation. Hearing loss may not be apparent at birth and thus requires close auditory follow up. Infants with confirmed hearing impairment may require hearing aids and may benefit from an early intervention program.<ref name=":2" />

Ophthalmologic Care

Eye abnormalities including cataracts, infantile glaucoma and retinopathy are common in infants born with CRS.<ref name=":3" /> Infants should undergo eye examinations after birth and during early childhood. Those with congenital eye defects require care from a pediatric ophthalmologist for specialized care and follow up.<ref name=":2" />

Cardiac Care

Congenital cardiac anomalies including pulmonary artery stenosis and patent ductus arteriosus can be seen in infants with CRS. Infants should undergo cardiac evaluation soon after birth and those with confirmed cardiac lesions will require specialized care with a pediatric cardiologist for any interventions and follow-up care.<ref name=":2" />

See also

• Jay Horwitz (born 1945), New York Mets executive born with the syndrome