Editing Dementia praecox

{{Short description|Obsolete medical term for the schizophrenia and autism spectrums}}
{{Distinguish|Early onset dementia}}
[[File:177 Eugen Bleuler 1911.jpg|thumb|right|A monograph by [[Eugen Bleuler]] on ''dementia praecox'' (1911)]]

'''Dementia praecox''' (meaning a "premature dementia" or "precocious madness") is a disused [[psychiatric]] diagnosis that originally designated a chronic, deteriorating [[psychotic disorder]] characterized by rapid cognitive disintegration, usually beginning in the late teens or early adulthood. Over the years, the term ''dementia praecox'' was gradually replaced by the term ''[[schizophrenia]]'', which initially had a meaning that included what is today considered the [[autism spectrum]].

The term ''dementia praecox'' was first used by German psychiatrist Heinrich Schüle in 1880.<ref>{{cite journal |vauthors=McNally K |date=December 2013 |title=Dementia praecox revisited |journal=History of Psychiatry |volume=24 |issue=4 |pages=507–509 |doi=10.1177/0957154X13501454 |pmid=24573761 |s2cid=206589195}}</ref>

It was also used in 1891 by [[Arnold Pick]] (1851–1924), a professor of psychiatry at [[Karl-Ferdinands-Universität|Charles University in Prague]].{{sfn|Hoenig|1995|p=337}} In a brief clinical report, he described a person with a psychotic disorder resembling "[[hebephrenia]]" (an adolescent-onset psychotic condition).

German psychiatrist [[Emil Kraepelin]] (1856–1926) popularised the term ''dementia praecox'' in his first detailed textbook descriptions of a condition that eventually became a different disease concept later relabeled as ''schizophrenia''.<ref>{{cite web |last=Yuhas |first=Daisy |title=Throughout History, Defining Schizophrenia Has Remained a Challenge (Timeline) |date=March 2013 |url=http://www.scientificamerican.com/article.cfm?id=throughout-history-defining-schizophrenia-has-remained-challenge |publisher=Scientific American Mind (March 2013) |access-date=2 March 2013}}</ref> Kraepelin reduced the complex psychiatric taxonomies of the nineteenth century by dividing them into two classes: manic-depressive psychosis and dementia praecox. This division, commonly referred to as the [[Kraepelinian dichotomy]], had a fundamental impact on twentieth-century psychiatry, though it has also been questioned.{{sfn|Greene|2007|p=361}}

The primary disturbance in dementia praecox was seen to be a disruption in cognitive or mental functioning in attention, memory, and goal-directed behaviour. Kraepelin contrasted this with manic-depressive psychosis, now termed [[bipolar disorder]], and also with other forms of [[mood disorder]], including [[major depressive disorder]]. Eventually, he concluded it was not possible to distinguish his categories on the basis of cross-sectional symptoms.{{sfn|Berrios|Luque|Villagran|2003|p=134}}

Kraepelin viewed dementia praecox as a progressively deteriorating disease from which no one recovered. However, by 1913, and more explicitly by 1920, Kraepelin admitted that while there may be a residual cognitive defect in most cases, the prognosis was not as uniformly dire as he had stated in the 1890s. Still, he regarded it as a specific disease concept that implied incurable, inexplicable madness.

==History==
{{blockquote|The history of dementia praecox is really that of psychiatry as a whole.|Adolf Meyer{{sfn|Sass|1994|p=[https://books.google.com/books?id=dwGeKBDa5-AC&pg=PA133]}}}}

===First use of the term===
[[File:Benedict-Augustin Morel (1809–1873).gif|thumb|Benedict Augustin Morel (1809–1873)]]
''[[Dementia]]'' is an ancient term which has been in use since at least the time of [[Lucretius]] in 50 BC where it meant "being out of one's mind".<ref>{{harvnb|Berrios|1996|p=[https://books.google.com/books?id=XSD_ucVR3E8C&pg=PA172 172]}}; {{harvnb|Malgorzata|Maganti|2004|p=2}}; {{harvnb|Bourgeois|2005|p=[https://books.google.com/books?id=PgRbFxayeQwC&pg=PA199 199]}}; {{harvnb|Adams|1997|p=[https://books.google.com/books?id=rMPxSrpr9YUC&pg=PA183 183]}}</ref> Until the seventeenth century, dementia referred to states of cognitive and behavioural deterioration leading to psychosocial incompetence. This condition could be innate or acquired, and the concept had no reference to a necessarily irreversible condition. It is the concept in this popular notion of psychosocial incapacity that forms the basis for the idea of legal incapacity.<ref>{{harvnb|Berrios|1996|p=[https://books.google.com/books?id=XSD_ucVR3E8C&pg=PA172 172]}}; {{harvnb|Berrios|Luque|Villagran|2003|p=116}}</ref> By the eighteenth century, at the period when the term entered into European medical discourse, clinical concepts were added to the vernacular understanding such that dementia was now associated with intellectual deficits arising from any cause and at any age.{{sfn|Berrios|Luque|Villagran|2003|p=116}} By the end of the nineteenth century, the modern 'cognitive paradigm' of dementia was taking root.{{sfn|Burns|2009|pp=199–200}} This holds that dementia is understood in terms of criteria relating to aetiology, age and course which excludes former members of the family of the demented such as adults with acquired head trauma or children with cognitive deficits. Moreover, it was now understood as an irreversible condition and a particular emphasis was placed on memory loss in regard to the deterioration of intellectual functions.{{sfn|Berrios|Luque|Villagran|2003|p=117}}

The term {{lang|fr|démence précoce}} was used in passing to describe the characteristics of a subset of young mental patients by the French physician [[Bénédict Morel|Bénédict Augustin Morel]] in 1852 in the first volume of his {{lang|fr|Études cliniques}}.<ref>{{harvnb|Hoenig|1995|p=337}}; {{harvnb|Boyle|2002|p=46}}. Berrios, Luque and Villagran contend in their 2003 article on schizophrenia that Morel's first use dates to the publication in 1860 of {{lang|fr|Traité des maladies mentales }} ({{harvnb|Berrios|Luque|Villagran|2003|p=117}}; {{harvnb|Morel|1860}}). Dowbiggin inaccurately states that Morel used the term on page 234 of the first volume of his 1852 publication {{lang|fr|Etudes cliniques}} ({{harvnb|Dowbiggin|1996|p=388}}; {{harvnb|Morel|1852|p=[https://books.google.com/books?id=n9hEAAAAcAAJ&pg=PA234 234]}}). On page 235 Morel does refer to {{lang|fr|démence juvénile}} in positing that senility is not an age specific condition and he also remarks that at his clinic he sees almost as many young people experiencing senility as old people ({{harvnb|Morel|1852|p=[https://books.google.com/books?id=n9hEAAAAcAAJ&pg=PA235 235]}}). Also, as Hoenig accurately states, Morel uses the term twice in his 1852 text on pages 282 and 361 ({{harvnb|Hoenig|1995|p=337}}; {{harvnb|Morel|1852|pp=[https://books.google.com/books?id=n9hEAAAAcAAJ&pg=PA282 282], [https://books.google.com/books?id=n9hEAAAAcAAJ&pg=PA361 361]}}). In the first instance the reference is made in relation to young girls of asthenic build who have often also had typhoid. It is a description and not a diagnostic category ({{harvnb|Morel|1852|p=[https://books.google.com/books?id=n9hEAAAAcAAJ&pg=PA282 282]}}). In the next instance the term is used to argue that the illness course for those with mania does not normally terminate in an early form of dementia ({{harvnb|Morel|1852|p=[https://books.google.com/books?id=n9hEAAAAcAAJ&pg=PA361 361]}}).</ref> and the term is used more frequently in his textbook {{lang|fr|Traité des maladies mentales}} which was published in 1860.<ref>{{harvnb|Berrios|Luque|Villagran|2003|p=117}}. The term {{lang|fr|démence précoce}} is used by Morel once in his 1857 text {{lang|fr|Traité des dégénérescence physiques, intellectuelles, et morales de l'espèce humaine}} ({{harvnb|Morel|1857|p=[https://books.google.com/books?id=lu85F4UGpT0C&pg=PA391 391]}}) and seven times in his 1860 book {{lang|fr|Traité des maladies mentales}} ({{harvnb|Morel|1860|pp=[https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA119 119], [https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA279 279], [https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA516 516], [https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA526 526], [https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA532 532], [https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA536 536], [https://books.google.com/books?id=yp8_AAAAcAAJ&pg=PA552 552]}}).</ref> Morel, whose name will be forever associated with religiously inspired concept of [[Social degeneration|degeneration theory]] in psychiatry, used the term in a descriptive sense and not to define a specific and novel diagnostic category. It was applied as a means of setting apart a group of young men and women with "stupor".{{sfn|Dowbiggin|1996|p=388}} As such their condition was characterised by a certain torpor, enervation, and disorder of the will and was related to the diagnostic category of [[melancholia]]. He did not conceptualise their state as irreversible and thus his use of the term dementia was equivalent to that formed in the eighteenth century as outlined above.{{sfn|Berrios|Luque|Villagran|2003|p=118}}

While some have sought to interpret, if in a qualified fashion, the use by Morel of the term {{lang|fr|démence précoce}} as amounting to the discovery of schizophrenia,{{sfn|Dowbiggin|1996|p=388}} others have argued convincingly that Morel's descriptive use of the term should not be considered in any sense as a precursor to Kraepelin's dementia praecox disease concept.{{sfn|Berrios|Luque|Villagran|2003|p=117}} This is due to the fact that their concepts of dementia differed significantly from each other, with Kraepelin employing the more modern sense of the word and that Morel was not describing a diagnostic category. Indeed, until the advent of Pick and Kraepelin, Morel's term had vanished without a trace and there is little evidence to suggest that either Pick or indeed Kraepelin were even aware of Morel's use of the term until long after they had published their own disease concepts bearing the same name.<ref>While Berrios, Luque and Villagran argue this point forcefully ({{harvnb|Berrios|Luque|Villagran|2003|p=117}}), others baldly state that Kraepelin was clearly inspired by Morel's lead. Yet no evidence of this claim is offered. For example, {{harvnb|Stone|2006|p=[https://books.google.com/books?id=bk4IPCprqicC&pg=PA1 1]}}.</ref> As Eugène Minkowski stated, "An abyss separates Morel's {{lang|fr|démence précoce|italics=no}} from that of Kraepelin."<ref>Quoted in {{harvnb|Berrios|Luque|Villagran|2003|p=117}}.</ref>

Morel described several psychotic disorders that ended in dementia, and as a result he may be regarded as the first alienist or psychiatrist to develop a diagnostic system based on presumed outcome rather than on the current presentation of signs and symptoms. Morel, however, did not conduct any long-term or [[quantitative research]] on the course and outcome of dementia praecox (Kraepelin would be the first in history to do that) so this prognosis was based on speculation. It is impossible to discern whether the condition briefly described by Morel was equivalent to the disorder later called dementia praecox by Pick and Kraepelin.

===Time component===
[[File:Karl Ludwig Kahlbaum.JPG|thumb|right|[[Karl Ludwig Kahlbaum]] (1828–1899)]]
Psychiatric [[nosology]] in the nineteenth-century was chaotic and characterised by a conflicting mosaic of contradictory systems.<ref>{{harvnb|Kraam|2008|p=77}}; {{harvnb|Jablensky|1999|p=96}}; {{harvnb|Scharfetter|2001|p=[http://www.sanp.ch/pdf/2001/2001-01/2001-01-058.PDF 34]}}; {{harvnb|Engstrom|2003|p=[https://books.google.com/books?id=C1JYNnBLMqQC&pg=PA27 27]}}</ref> Psychiatric disease categories were based upon short-term and [[cross-sectional]] observations of patients from which were derived the putative characteristic [[medical sign|signs]] and [[symptoms]] of a given disease concept.<ref>{{harvnb|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA145 145]}}; {{harvnb|Hoenig|1995|pp=337–8}}; {{harvnb|Kraam|2009|p=88}}</ref> The dominant psychiatric paradigms which gave a semblance of order to this fragmentary picture were Morelian degeneration theory and the concept of "[[unitary psychosis]]" ({{lang|de|Einheitspsychose}}).<ref>{{harvnb|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA145 145]}}; {{harvnb|Engstrom|2003|p=[https://books.google.com/books?id=C1JYNnBLMqQC&pg=PA27 27]}}</ref> This latter notion, derived from the Belgian psychiatrist [[Joseph Guislain]] (1797–1860), held that the variety of symptoms attributed to mental illness were manifestations of a single underlying disease process.<ref>{{harvnb|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA145 145]}}</ref> While these approaches had a diachronic aspect they lacked a conception of mental illness that encompassed a coherent notion of change over time in terms of the natural course of the illness and based upon an empirical observation of changing symptomatology.{{sfn|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA242 242]}}

In 1863, the [[Danzig]]-based psychiatrist [[Karl Ludwig Kahlbaum]] (1828–1899) published his text on psychiatric nosology {{lang|de|Die Gruppierung der psychischen Krankheiten}} (''The Classification of Psychiatric Diseases'').<ref>{{harvnb|Engstrom|2003|p=[https://books.google.com/books?id=C1JYNnBLMqQC&pg=PA263 263]}}; {{harvnb|Pillmann|Marneros|2003|p=163}}; {{harvnb|Kahlbaum|1863}}</ref> Although with the passage of time this work would prove profoundly influential, when it was published it was almost completely ignored by German academia despite the sophisticated and intelligent disease classification system which it proposed.{{sfn|Kraam|2009|p=87}} In this book Kahlbaum categorized certain typical forms of psychosis ({{lang|la|vesania typica}}) as a single coherent type based upon their shared progressive nature which betrayed, he argued, an ongoing degenerative disease process.<ref>{{harvnb|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA242 242]}}; {{harvnb|Pillmann|Marneros|2003|p=163}}</ref> For Kahlbaum the disease process of {{lang|la|vesania typica}} was distinguished by the passage of the patient through clearly defined disease phases: a melancholic stage; a manic stage; a confusional stage; and finally a demented stage.<ref>{{harvnb|Kraam|2009|p=105}}; {{harvnb|Kahlbaum|1863|p=[https://books.google.com/books?id=zYY_AAAAcAAJ&pg=PA135 135]}}</ref>

In 1866, Kahlbaum became the director of a private psychiatric clinic in [[Görlitz]] ([[Kingdom of Prussia|Prussia]], today [[Saxony]], a small town near [[Dresden]]). He was accompanied by his younger assistant, [[Ewald Hecker]] (1843–1909), and during a ten-year collaboration they conducted a series of [[research]] studies on young psychotic patients that would become a major influence on the development of modern psychiatry.

Together Kahlbaum and Hecker were the first to describe and name such [[syndrome]]s as [[dysthymia]], [[cyclothymia]], [[paranoia]], [[catatonia]], and [[hebephrenia]].{{sfn|Porter|1999|p=512}} Perhaps their most lasting contribution to psychiatry was the introduction of the "clinical method" from medicine to the study of mental diseases, a method which is now known as [[psychopathology]].

When the element of time was added to the concept of [[medical diagnosis|diagnosis]], a diagnosis became more than just a description of a collection of symptoms: diagnosis now also defined by [[prognosis]] (course and outcome). An additional feature of the clinical method was that the characteristic symptoms that define syndromes should be described without any prior assumption of brain pathology (although such links would be made later as scientific knowledge progressed). Karl Kahlbaum made an appeal for the adoption of the clinical method in psychiatry in his 1874 book on catatonia. Without Kahlbaum and Hecker there would be no dementia praecox.{{sfn|Hoenig|1995|pp=337–8}}

Upon his appointment to a full professorship in psychiatry at the University of Dorpat (now [[Tartu]], Estonia) in 1886, Kraepelin gave an inaugural address to the faculty outlining his research programme for the years ahead. Attacking the "brain mythology" of [[Theodor Meynert|Meynert]] and the positions of [[Wilhelm Griesinger|Griesinger]] and [[Bernhard von Gudden|Gudden]], [[Emil Kraepelin|Kraepelin]] advocated that the ideas of Kahlbaum, who was then a marginal and little known figure in psychiatry, should be followed. Therefore, he argued, a research programme into the nature of psychiatric illness should look at a large number of patients over time to discover the course which mental disease could take.{{sfn|Steinberger|Angermeyer|2001|pp=297–327}} It has also been suggested that Kraepelin's decision to accept the Dorpat post was informed by the fact that there he could hope to gain experience with chronic patients and this, it was presumed, would facilitate the longitudinal study of mental illness.{{sfn|Berrios|1996|p=[https://books.google.com/books?id=XSD_ucVR3E8C&pg=PA23 23]}}

===Quantitative component===
Understanding that objective diagnostic methods must be based on scientific practice, Kraepelin had been conducting psychological and drug experiments on patients and normal subjects for some time when, in 1891, he left Dorpat and took up a position as professor and director of the psychiatric clinic at [[Heidelberg University]]. There he established a research program based on Kahlbaum's proposal for a more exact qualitative clinical approach, and his own innovation: a quantitative approach involving meticulous collection of data over time on each new patient admitted to the clinic (rather than only the interesting cases, as had been the habit until then).

Kraepelin believed that by thoroughly describing all of the clinic's new patients on index cards, which he had been using since 1887, [[researcher]] bias could be eliminated from the investigation process.{{sfn|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PR14 xiv]}} He described the method in his posthumously published memoir:
{{blockquote|... after the first thorough examination of a new patient, each of us had to throw in a note [in a "diagnosis box"] with his diagnosis written on it. After a while, the notes were taken out of the box, the diagnoses were listed, and the case was closed, the final interpretation of the disease was added to the original diagnosis. In this way, we were able to see what kind of mistakes had been made and were able to follow-up the reasons for the wrong original diagnosis.<ref>{{harvnb|Kraepelin|1987|p=61}}</ref>}}

The fourth edition of his textbook, {{lang|de|Psychiatrie}}, published in 1893, two years after his arrival at Heidelberg, contained some impressions of the patterns Kraepelin had begun to find in his index cards. Prognosis (course and outcome) began to feature alongside signs and symptoms in the description of syndromes, and he added a class of psychotic disorders designated "psychic degenerative processes", three of which were borrowed from Kahlbaum and Hecker: ''dementia paranoides'' (a degenerative type of Kahlbaum's paranoia, with sudden onset), ''catatonia'' (per Kahlbaum, 1874) and ''dementia praecox'', (Hecker's hebephrenia of 1871). Kraepelin continued to equate dementia praecox with hebephrenia for the next six years.{{sfn|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PR14 xiv]}}

In the March 1896 fifth edition of {{lang|de|Psychiatrie}}, Kraepelin expressed confidence that his [[clinical trial|clinical]] [[scientific method|method]], involving analysis of both [[qualitative research|qualitative]] and [[quantitative research|quantitative]] data derived from long term observation of patients, would produce reliable diagnoses including prognosis:
{{blockquote|What convinced me of the superiority of the clinical method of diagnosis (followed here) over the traditional one, was the certainty with which we could predict (in conjunction with our new concept of disease) the future course of events. Thanks to it the student can now find his way more easily in the difficult subject of psychiatry.<ref>{{harvnb|Kraepelin|1896|p=v}} quoted in {{harvnb|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PR14 xiv]}}</ref>}}
In this edition dementia praecox is still essentially hebephrenia, and it, dementia paranoides and catatonia are described as distinct psychotic disorders among the "metabolic disorders leading to dementia".<ref>{{harvnb|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PR14 xiv]}}</ref>

==Kraepelin's influence on the next century==
[[File:Emil Kraepelin 1926.jpg|thumb|right|Emil Kraepelin {{Circa|1920}}]]
In the 1899 (6th) edition of {{lang|de|Psychiatrie}}, Kraepelin established a paradigm for psychiatry that would dominate the following century, sorting most of the recognized forms of insanity into two major categories: dementia praecox and manic-depressive illness. Dementia praecox was characterized by disordered intellectual functioning, whereas manic-depressive illness was principally a disorder of affect or mood; and the former featured constant deterioration, virtually no recoveries and a poor outcome, while the latter featured periods of exacerbation followed by periods of remission, and many complete recoveries. The class, dementia praecox, comprised the paranoid, catatonic and hebephrenic psychotic disorders, and these forms were found in the [[Diagnostic and Statistical Manual of Mental Disorders]] until the fifth edition was released, in May 2013. These terms, however, are still found in general psychiatric nomenclature.{{cn|date=May 2022}}

===Change in prognosis===
In the seventh, 1904, edition of {{lang|de|Psychiatrie}}, Kraepelin accepted the possibility that a small number of patients may recover from dementia praecox. [[Eugen Bleuler]] reported in 1908 that in many cases there was no inevitable progressive decline, there was temporary remission in some cases, and there were even cases of near recovery with the retention of some residual defect. In the eighth edition of Kraepelin's textbook, published in four volumes between 1909 and 1915, he described eleven forms of dementia, and dementia praecox was classed as one of the "endogenous dementias". Modifying his previous more gloomy prognosis in line with Bleuler's observations, Kraepelin reported that about 26% of his patients experienced partial remission of symptoms. Kraepelin died while working on the ninth edition of {{lang|de|Psychiatrie}} with Johannes Lange (1891–1938), who finished it and brought it to publication in 1927.<ref>{{harvnb|Noll|2007a|pp=[https://books.google.com/books?id=jzoJxps189IC&pg=PA126 126–7]}}</ref>

===Cause===
Though his work and that of his research associates had revealed a role for heredity, Kraepelin realized nothing could be said with certainty about the aetiology of dementia praecox, and he left out speculation regarding brain disease or neuropathology in his diagnostic descriptions. Nevertheless, from the 1896 edition onwards Kraepelin made clear his belief that poisoning of the brain, "auto-intoxication," probably by sex hormones, may underlie dementia praecox&nbsp;– a theory also entertained by Eugen Bleuler. Both theorists insisted dementia praecox is a biological disorder, not the product of psychological trauma. Thus, rather than a disease of hereditary degeneration or of structural brain pathology, Kraepelin believed dementia praecox was due to a systemic or "whole body" disease process, probably metabolic, which gradually affected many of the tissues and organs of the body before affecting the brain in a final, decisive cascade.<ref>{{cite web|last=Noll|first=Richard|title=Whole Body Madness|url=http://www.psychiatrictimes.com/display/article/10168/2104852|publisher=Psychiatric times|access-date=26 September 2012}}</ref> Kraepelin, recognizing dementia praecox in Chinese, Japanese, Tamil and Malay patients, suggested in the eighth edition of {{lang|de|Psychiatrie}} that, "we must therefore seek the real cause of dementia praecox in conditions which are spread all over the world, which thus do not lie in race or in climate, in food or in any other general circumstance of life..."{{sfn|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA127 127]}}

===Treatment===
Kraepelin had experimented with hypnosis but found it wanting, and disapproved of Freud's and Jung's introduction, based on no evidence, of psychogenic assumptions to the interpretation and treatment of mental illness. He argued that, without knowing the underlying cause of dementia praecox or manic-depressive illness, there could be no disease-specific treatment, and recommended the use of long baths and the occasional use of drugs such as opiates and barbiturates for the amelioration of distress, as well as occupational activities, where suitable, for all institutionalized patients. Based on his theory that dementia praecox is the product of autointoxication emanating from the sex glands, Kraepelin experimented, without success, with injections of thyroid, gonad and other glandular extracts.{{sfn|Noll|2007a|p=[https://books.google.com/books?id=jzoJxps189IC&pg=PA127 127]}}

===Use of term spreads===
[[File:Cartoon by Emil Kraepelin.jpg|right|thumb|"Psychiatrists of Europe! Protect your sanctified diagnoses!" A satirizing cartoon by Emil Kraepelin based on [[:de:Völker Europas, wahrt eure heiligsten Güter|a famous contemporary political painting]] (Below).]]
[[File:Voelker Europas.jpg|right|thumb|The political painting {{lang|de|Völker Europas, wahrt eure heiligsten Güter|}} ("People of Europe, defend your sacred treasures!")]]
Kraepelin noted the dissemination of his new disease concept when in 1899 he enumerated the term's appearance in almost twenty articles in the German-language medical press.{{sfn| Noll| 2007a|p = [https://books.google.com/books?id=jzoJxps189IC&pg=PA127 127]}} In the early years of the twentieth century the twin pillars of the Kraepelinian dichotomy, dementia praecox and manic depressive psychosis, were assiduously adopted in clinical and research contexts among the Germanic psychiatric community.{{sfn|Noll|2007a|p= [https://books.google.com/books?id=jzoJxps189IC&pg=PA127 127]}} German-language psychiatric concepts were always introduced much faster in America (than, say, Britain) where émigré German, Swiss and Austrian physicians essentially created American psychiatry. Swiss-émigré Adolf Meyer (1866–1950), arguably the most influential psychiatrist in America for the first half of the 20th century, published the first critique of dementia praecox in an 1896 book review of the 5th edition of Kraepelin's textbook. But it was not until 1900 and 1901 that the first three American publications regarding dementia praecox appeared, one of which was a translation of a few sections of Kraepelin's 6th edition of 1899 on dementia praecox.

Adolf Meyer was the first to apply the new diagnostic term in America. He used it at the Worcester Lunatic Hospital in Massachusetts in the fall of 1896. He was also the first to apply Eugen Bleuler's term "schizophrenia" (in the form of "schizophrenic reaction") in 1913 at the Henry Phipps Psychiatric Clinic of the Johns Hopkins Hospital.

The dissemination of Kraepelin's disease concept to the Anglophone world was facilitated in 1902 when Ross Diefendorf, a lecturer in psychiatry at Yale, published an adapted version of the sixth edition of the {{lang|de|Lehrbuch der Psychiatrie}}. This was republished in 1904 and with a new version, based on the seventh edition of Kraepelin's {{lang|de|Lehrbuch}} appearing in 1907 and reissued in 1912.{{Sfn |Dain|1980|pp=[https://books.google.com/books?id=OJMgz7cJjLcC&pg=PA34 34], [https://books.google.com/books?id=OJMgz7cJjLcC&pg=PA341 341 n. 38]}}{{Sfn |Diefendorf|1912|pp=219–75}} Both dementia praecox (in its three classic forms) and "manic-depressive psychosis" gained wider popularity in the larger institutions in the eastern United States after being included in the official nomenclature of diseases and conditions for record-keeping at Bellevue Hospital in New York City in 1903. The term lived on due to its promotion in the publications of the National Committee on Mental Hygiene (founded in 1909) and the Eugenics Records Office (1910). But perhaps the most important reason for the longevity of Kraepelin's term was its inclusion in 1918 as an official diagnostic category in the uniform system adopted for comparative statistical record-keeping in all American mental institutions, ''The Statistical Manual for the Use of Institutions for the Insane''. Its many revisions served as the official diagnostic classification scheme in America until 1952 when the first edition of the ''Diagnostic and Statistical Manual: Mental Disorders'', or DSM-I, appeared. Dementia praecox disappeared from official psychiatry with the publication of DSM-I, replaced by the Bleuler/Meyer hybridization, "schizophrenic reaction".

Schizophrenia was mentioned as an alternate term for dementia praecox in the 1918 ''Statistical Manual''. In both clinical work as well as research, between 1918 and 1952 five different terms were used interchangeably: dementia praecox, schizophrenia, dementia praecox (schizophrenia), schizophrenia (dementia praecox) and schizophrenic reaction. This made the psychiatric literature of the time confusing since, in a strict sense, Kraepelin's disease was not Bleuler's disease. They were defined differently, had different population parameters, and different concepts of prognosis.

The reception of dementia praecox as an accepted diagnosis in British psychiatry came more slowly, perhaps only taking hold around the time of World War I. There was substantial opposition to the use of the term "dementia" as misleading, partly due to findings of remission and recovery. Some argued that existing diagnoses such as "delusional insanity" or "adolescent insanity" were better or more clearly defined.<ref>{{harvnb|Ion|Beer|2002a|pp=285–304}}; {{harvnb|Ion|Beer|2002b|pp=419–31}}</ref> In France a psychiatric tradition regarding the psychotic disorders predated Kraepelin, and the French never fully adopted Kraepelin's classification system. Instead the French maintained an independent classification system throughout the 20th century. From 1980, when DSM-III totally reshaped psychiatric diagnosis, French psychiatry began to finally alter its views of diagnosis to converge with the North American system. Kraepelin thus finally conquered France via America.

==From dementia praecox to schizophrenia==
{{See also|History of schizophrenia}}

Due to the influence of alienists such as Adolf Meyer, August Hoch, George Kirby, Charles Macphie Campbell, Smith Ely Jelliffe and William Alanson White, psychogenic theories of dementia praecox dominated the American scene by 1911. In 1925 Bleuler's schizophrenia rose in prominence as an alternative to Kraepelin's dementia praecox. When Freudian perspectives became influential in American psychiatry in the 1920s schizophrenia became an attractive alternative concept. Bleuler corresponded with Freud and was connected to Freud's psychoanalytic movement,<ref>{{cite book |last=Makari |first=George |title=Revolution in Mind: The Creation of Psychoanalysis |publisher=Harper Perennial |location=New York |year=2008}}</ref> and the inclusion of Freudian interpretations of the symptoms of schizophrenia in his publications on the subject, as well as those of C.G. Jung, eased the adoption of his broader version of dementia praecox (schizophrenia) in America over Kraepelin's narrower and prognostically more negative one.

The term "schizophrenia" was first applied by American alienists and neurologists in private practice by 1909 and officially in institutional settings in 1913, but it took many years to catch on. It is first mentioned in ''[[The New York Times]]'' in 1925. Until 1952 the terms dementia praecox and schizophrenia were used interchangeably in American psychiatry, with occasional use of the hybrid terms "dementia praecox (schizophrenia)" or "schizophrenia (dementia praecox)".

==Diagnostic manuals==
Editions of the Diagnostic and Statistical Manual of Mental Disorders since the first in 1952 had reflected views of schizophrenia as "reactions" or "psychogenic" (DSM-I), or as manifesting Freudian notions of "defense mechanisms" (as in DSM-II of 1969 in which the symptoms of schizophrenia were interpreted as "psychologically self-protected"). The diagnostic criteria were vague, minimal and wide, including either concepts that no longer exist or that are now labeled as personality disorders (for example, schizotypal personality disorder). There was also no mention of the dire prognosis Kraepelin had made. Schizophrenia seemed to be more prevalent and more psychogenic and more treatable than either Kraepelin or Bleuler would have allowed.

==Conclusions==
As a direct result of the effort to construct [[Research Diagnostic Criteria]] in the 1970s that were independent of any clinical diagnostic manual, Kraepelin's idea that categories of mental disorder should reflect discrete and specific disease entities with a biological basis began to return to prominence. Vague dimensional approaches based on symptoms—so highly favored by the Meyerians and psychoanalysts—were overthrown. For research purposes, the definition of schizophrenia returned to the narrow range allowed by Kraepelin's dementia praecox concept. Furthermore, after 1980 the disorder was a progressively deteriorating one once again, with the notion that recovery, if it happened at all, was rare. This revision of schizophrenia became the basis of the diagnostic criteria in DSM-III (1980). Some of the psychiatrists who worked to bring about this revision referred to themselves as the "neo-Kraepelinians".

==Footnotes==
{{Reflist}}

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==Further reading==
* Bibliography of scholarly histories on schizophrenia and dementia praecox, [http://ahp.yorku.ca/?p=86 part 1] (2000&nbsp;– mid 2007).
* Burgmair, Wolfgang & Eric J. Engstrom & Matthias Weber, et al., eds. ''Emil Kraepelin''. 8 vols. Munich: Belleville, 2000–2013.
** Vol. VIII. Kraepelin in München, Teil III: 1921–1926 (2013), {{ISBN|978-3-943157-22-2}}.
** Vol. VII: Kraepelin in München, Teil II: 1914–1926 (2008).
** Vol. VI: Kraepelin in München, Teil I: 1903–1914 (2006), {{ISBN|3-933510-95-3}}
** Vol. V: Kraepelin in Heidelberg, 1891–1903 (2005), {{ISBN|3-933510-94-5}}
** Vol. IV: Kraepelin in Dorpat, 1886–1891 (2003), {{ISBN|3-933510-93-7}}
** Vol. III: Briefe I, 1868–1886 (2002), {{ISBN|3-933510-92-9}}
** Vol. II: Kriminologische und forensische Schriften: Werke und Briefe (2001), {{ISBN|3-933510-91-0}}
** Vol. I: Persönliches, Selbstzeugnisse (2000), {{ISBN|3-933510-90-2}}
* Engels, Huub (2006). ''Emil Kraepelins Traumsprache'' 1908–1926. annotated edition of Kraepelin's [[dream speech]] in the mentioned period. {{ISBN|978-90-6464-060-5}}.
* [[Emil Kraepelin|Kraepelin, Emil]]. ''Psychiatrie: Ein kurzes Lehrbuch fur Studirende und Aerzte. Vierte, vollständig umgearbeitete Auflage.'' Leipzig: Abel Verlag, 1893.
* Kraepelin, Emil. ''Psychiatrie: Ein Lehrbuch fur Studirende und Aerzte. Fünfte, vollständig umgearbeitete Auflage.'' Leipzig: Verlag von Johann Ambrosius Barth, 1896.
* Kraepelin, Emil. ''Psychiatrie: Ein Lehrbuch fur Studirende und Aerzte. Sechste, vollständig umgearbeitete Auflage.'' Leipzig: Verlag von Johann Ambrosius Barth, 1899.
* Pick, Arnold. Ueber primare chronische Demenz (so. Dementia praecox) im jugendlichen Alter. ''Prager medicinische Wochenschrift'', 1891, 16: 312–315.

==See also==
{{Portal|Psychiatry}}
*[[Daniel Paul Schreber]], a famous case of dementia praecox.

==External links==
*{{Commons category-inline}}

{{Use dmy dates|date=March 2017}}

{{DEFAULTSORT:Dementia Praecox}}
[[Category:Obsolete terms for mental disorders]]
[[Category:Obsolete medical terms]]
[[Category:Schizophrenia]]