Editing Chromosome 15q trisomy

{{Infobox medical condition (new)
| name            = Chromosome 15q trisomy
| synonyms        = '''duplication 15 q'''
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'''Chromosome 15q duplication''' is an extremely rare [[genetic disorder]] in which there is an excess copy of a segment of DNA found on the long ("q") arm of [[human]] [[chromosome 15]]. As a result, affected cells contain a total of 3 copies of the duplicated bases, instead of the usual 2 copies - one inherited from the mother and one from the father - found in a normal human diploid genome.

==Signs and symptoms==
The disorder is primarily characterized by growth abnormalities, which range from growth retardation to accelerated growth, [[intellectual disability]], and distinctive malformations of the [[head (anatomy)|head]] and [[face]]. Additional abnormalities may involve malformation of the [[skeleton]], [[vertebral column|spine]] and [[neck]]; [[finger]]s and/or [[toe]]s; [[genital]]s (particularly in males); and, in some cases, [[heart]] problems and [[seizures]].<ref name=NORD>{{cite web |title=Chromosome 15, Distal Trisomy 15q |url=https://rarediseases.org/rare-diseases/chromosome-15-distal-trisomy-15q/ |website=NORD (National Organization for Rare Disorders) |access-date=23 April 2019}}</ref><ref>{{cite web |title=Chromosome 15q duplication {{!}} Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |url=https://rarediseases.info.nih.gov/diseases/5314/chromosome-15q-duplication |website=rarediseases.info.nih.gov |access-date=23 April 2019}}</ref>

==Diagnosis==

The diagnosis of partial trisomy 15q can be made prenatally or postnatally.

The method used for precise diagnosis depends on a number of factors, including the size of the segment of duplicated material, its location, its orientation (inverted), and others.

==Treatment==
The condition is incurable and treatment is based on alleviating symptoms.<ref name=NORD/>

==Epidemiology==
C15 trisomy affects twice as many males as females. Fewer than 50 cases have been reported.<ref name=NORD/>

==See also==
* [[Chromosome 15q partial deletion]]

==References==
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{{Medical resources
|  ICD10           = Q92.3
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|  MeSH            = C538036
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|  Orphanet        = 1707
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{{DEFAULTSORT:Chromosome 15q Trisomy}}
[[Category:Genetic disorders with no OMIM]]