Editing Transdifferentiation (section)

=== Mogrify algorithm ===
Determining the unique set of cellular factors that is needed to be manipulated for each cell conversion is a long and costly process that involved much trial and error. As a result, this first step of identifying the key set of cellular factors for cell conversion is the major obstacle researchers face in the field of cell reprogramming. An international team of researchers have developed an algorithm, called Mogrify(1), that can predict the optimal set of cellular factors required to convert one human cell type to another. When tested, Mogrify was able to accurately predict the set of cellular factors required for previously published cell conversions correctly. To further validate Mogrify's predictive ability, the team conducted two novel cell conversions in the laboratory using human cells, and these were successful in both attempts solely using the predictions of Mogrify.<ref>[http://www.eurekalert.org/pub_releases/2016-01/dms-moc011516.php  Mapping out cell conversion]</ref><ref>{{cite journal | last1 = Owen | first1 = Rackham | last2 = Gough | first2 = Julian  | year = 2016 | title = A predictive computational framework for direct reprogramming between human cell types | journal = Nature Genetics| volume =  48| issue = 3| pages =  331–335| doi = 10.1038/ng.3487 | pmid=26780608| url = https://research-information.bris.ac.uk/en/publications/a-predictive-computational-framework-for-direct-reprogramming-between-human-cell-types(e6490a78-f3e8-4253-acc4-7ee181c79168).html | hdl = 1983/e6490a78-f3e8-4253-acc4-7ee181c79168 | s2cid = 217524918 | hdl-access = free }}</ref><ref>Jane Byrne (Jul 2021). [https://www.biopharma-reporter.com/Article/2021/07/01/Mogrify-looks-to-transform-cell-therapy-development  Mogrify looks to transform cell therapy development]. BIOPHARMA-REPORTER.COM</ref> Mogrify has been made available online for other researchers and scientists.