Editing Strychnine (section)

=== Other treatments ===
Most other treatment options focus on controlling the convulsions that arise from strychnine poisoning. These treatments involve keeping the patient in a quiet and darkened room,<ref>{{Cite web |title=Drugs and Poisons Fact Sheet: Strychnine Permits - What you need to know |url=https://www.bulloo.qld.gov.au/downloads/file/978/9-strychnine-guide |access-date=12 August 2024 |publisher=Queensland Health}}</ref> [[anticonvulsants]] such as [[phenobarbital]] or [[diazepam]],<ref name="CDC_card2" /> muscle relaxants such as [[dantrolene]],<ref>{{Cite web |title=Final Diagnosis -- Case 550 |url=https://path.upmc.edu/cases/case550/dx.html |access-date=2024-08-12 |website=path.upmc.edu}}</ref> barbiturates and [[propofol]],<ref>{{cite journal |vauthors=Lages A, Pinho J, Alves R, Capela C, Lourenço E, Lencastre L |date=16 May 2013 |title=Strychnine Intoxication: A Case Report |journal=Journal of Medical Cases |volume=4 |issue=6 |pages=385–388 |doi=10.4021/jmc1189w |s2cid=54707248 |doi-access=free}}</ref> and [[chloroform]] or heavy doses of [[chloral]], [[bromide]], [[Ethyl carbamate|urethane]] or [[amyl nitrite]].<ref>{{cite book |title=Pharmacology and Therapeutics |vauthors=Cushny AR |date=January 1, 1940 |publisher=Lea & Febiger |edition=12 |asin=B000SNDA1U}}</ref><ref name="pmid296408802">{{cite journal |vauthors=Buckley S |date=September 1873 |title=Case of Strychnine Poisoning Successfully Treated by Atropine |journal=Edinburgh Medical Journal |volume=19 |issue=3 |pages=211–213 |pmc=5315983 |pmid=29640880 |s2cid=4760315}}</ref><ref>{{cite journal |date=1932 |title=The Treatment of Strychnine Poisoning |url=https://jamanetwork.com/journals/jama/article-abstract/280615 |url-status=live |journal=Journal of the American Medical Association |volume=98 |issue=23 |page=1992 |doi=10.1001/jama.1932.02730490038013 |archive-url=https://web.archive.org/web/20240206023304/https://jamanetwork.com/journals/jama/article-abstract/280615 |archive-date=2024-02-06 |access-date=2024-02-06}}</ref><ref>{{cite web |date=8 September 2021 |title=Strychnine and Vomit: The Untold Story of Past US Addiction Treatments |url=https://filtermag.org/strychnine-addiction-treatments/ |url-status=live |archive-url=https://web.archive.org/web/20240206023305/https://filtermag.org/strychnine-addiction-treatments/ |archive-date=6 February 2024 |access-date=6 February 2024}}</ref> If a poisoned person is able to survive for 6 to 12 hours subsequent to initial dose, they have a good prognosis.<ref name="CDC_card2" />

The [[Sine qua non#Usage in medicine|sine qua non]] of strychnine toxicity is the "awake" seizure, in which tonic-clonic activity occurs but the patient is alert and oriented throughout and afterwards.<ref>{{cite journal |vauthors=Boyd RE, Brennan PT, Deng JF, Rochester DF, Spyker DA |date=March 1983 |title=Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis |journal=The American Journal of Medicine |volume=74 |issue=3 |pages=507–512 |doi=10.1016/0002-9343(83)90999-3 |pmid=6829597 |s2cid=3222667}}</ref> Accordingly, [[George Harley (physician)|George Harley]] (1829–1896) showed in 1850 that [[curare]] (wourali) was [[Curare#History|effective]] for the treatment of tetanus and strychnine poisoning.