Editing Riboflavin (section)

==Uses==
===Treatment of corneal thinning===
[[Keratoconus]] is the most common form of [[corneal ectasia]], a progressive thinning of the cornea. The condition is treated by [[Corneal cross-linking|corneal collagen cross-linking]], which increases corneal stiffness. Cross-linking is achieved by applying a [[topical medication|topical]] riboflavin solution to the cornea, which is then exposed to [[Ultraviolet#UVA|ultraviolet A]] light.<ref>{{cite journal | vauthors = Mastropasqua L | title = Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives | journal = Eye and Vision | volume = 2 | pages = 19 | date = 2015 | pmid = 26665102 | pmc = 4675057 | doi = 10.1186/s40662-015-0030-6 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Sorkin N, Varssano D | title = Corneal collagen crosslinking: a systematic review | journal = Ophthalmologica | volume = 232 | issue = 1 | pages = 10–27 | date = June 2014 | pmid = 24751584 | doi = 10.1159/000357979 | s2cid = 32696531 | doi-access = free }}</ref>

===Migraine prevention===
In its 2012 guidelines, the [[American Academy of Neurology]] stated that high-dose riboflavin (400&nbsp;mg) is "probably effective and should be considered for migraine prevention,"<ref name="Holland">{{cite journal | vauthors = Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E | title = Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society | journal = Neurology | volume = 78 | issue = 17 | pages = 1346–53 | date = April 2012 | pmid = 22529203 | pmc = 3335449 | doi = 10.1212/wnl.0b013e3182535d0c }}</ref> a recommendation also provided by the UK National Migraine Centre.<ref name="nmc">{{cite web |title="Natural" remedies for migraine – should I try them? |url=https://www.nationalmigrainecentre.org.uk/migraine-and-headaches/migraine-and-headache-factsheets/natural-remedies-for-migraine-should-i-try-them/ |publisher=UK National Migraine Centre |access-date=8 October 2021 |date=2021 |archive-date=8 October 2021 |archive-url=https://web.archive.org/web/20211008155921/https://www.nationalmigrainecentre.org.uk/migraine-and-headaches/migraine-and-headache-factsheets/natural-remedies-for-migraine-should-i-try-them/ |url-status=live }}</ref> A 2017 review reported that daily riboflavin taken at 400&nbsp;mg per day for at least three months may reduce the frequency of [[migraine]] headaches in adults.<ref name="Thompson2017">{{cite journal | vauthors = Thompson DF, Saluja HS | title = Prophylaxis of migraine headaches with riboflavin: A systematic review | journal = Journal of Clinical Pharmacy and Therapeutics | volume = 42 | issue = 4 | pages = 394–403 | date = August 2017 | pmid = 28485121 | doi = 10.1111/jcpt.12548 | s2cid = 29848028 | doi-access = free }}</ref> Research on high-dose riboflavin for migraine prevention or treatment in children and adolescents is inconclusive, and so supplements are not recommended.<ref name=drugs/><ref name=ods/><ref name="Sherwood">{{cite journal | vauthors = Sherwood M, Goldman RD | title = Effectiveness of riboflavin in pediatric migraine prevention | journal = Canadian Family Physician | volume = 60 | issue = 3 | pages = 244–6 | date = March 2014 | pmid = 24627379 | pmc = 3952759 }}</ref>

===Food coloring===
Riboflavin is used as a [[food coloring]] (yellow-orange crystalline powder),<ref name=pubchem/> and is designated with the [[E number]], E101, in Europe for use as a [[food additive]].<ref name=UKFSA>{{cite web|url=https://www.food.gov.uk/business-guidance/approved-additives-and-e-numbers|title=Approved additives and E numbers|website=food.gov.uk|access-date=20 August 2023|date=10 August 2023|publisher=UK Food Standards Agency|archive-date=26 September 2020|archive-url=https://web.archive.org/web/20200926032802/https://www.food.gov.uk/business-guidance/approved-additives-and-e-numbers/|url-status=live}}</ref>