Editing Prion (section)

==== PrP and long-term memory ====
A review of evidence in 2005 suggested that PrP may have a normal function in the maintenance of [[long-term memory]].<ref>{{cite journal | vauthors = Shorter J, Lindquist S | title = Prions as adaptive conduits of memory and inheritance | journal = Nature Reviews. Genetics | volume = 6 | issue = 6 | pages = 435–450 | date = June 2005 | pmid = 15931169 | doi = 10.1038/nrg1616 | s2cid = 5575951 }}</ref> As well, a 2004 study found that mice lacking genes for normal cellular PrP protein show altered [[hippocampus|hippocampal]] [[long-term potentiation]].<ref>{{cite journal | vauthors = Maglio LE, Perez MF, Martins VR, Brentani RR, Ramirez OA | title = Hippocampal synaptic plasticity in mice devoid of cellular prion protein | journal = Brain Research. Molecular Brain Research | volume = 131 | issue = 1–2 | pages = 58–64 | date = November 2004 | pmid = 15530652 | doi = 10.1016/j.molbrainres.2004.08.004 }}</ref><ref>{{cite journal | vauthors = Caiati MD, Safiulina VF, Fattorini G, Sivakumaran S, Legname G, Cherubini E | title = PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus | journal = The Journal of Neuroscience | volume = 33 | issue = 7 | pages = 2973–83 | date = February 2013 | pmid = 23407955 | pmc = 6619229 | doi = 10.1523/JNEUROSCI.4149-12.2013 }}</ref> A recent study that also suggests why this might be the case, found that neuronal protein [[CPEB]] has a similar genetic sequence to yeast prion proteins. The prion-like formation of CPEB is essential for maintaining long-term synaptic changes associated with long-term memory formation.<ref>{{cite journal | vauthors = Sudhakaran IP, Ramaswami M | title = Long-term memory consolidation: The role of RNA-binding proteins with prion-like domains | journal = RNA Biology | volume = 14 | issue = 5 | pages = 568–586 | date = May 2017 | pmid = 27726526 | pmc = 5449092 | doi = 10.1080/15476286.2016.1244588 }}</ref>