Editing Peptidoglycan (section)

==== Toll-like receptors ====
The role of [[Toll-like receptor|TLRs]] in direct recognition of peptidoglycan is controversial.<ref name="Wolf-2018" /> In some studies, has been reported that peptidoglycan is sensed by [[Toll-like receptor 2|TLR2]].<ref>{{cite journal | vauthors = Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D | title = Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2 | journal = Journal of Immunology | volume = 163 | issue = 1 | pages = 1–5 | date = July 1999 | doi = 10.4049/jimmunol.163.1.1 | pmid = 10384090 | s2cid = 23630870 | doi-access = free }}</ref> But this TLR2-inducing activity could be due to cell wall [[lipoprotein]]s and [[lipoteichoic acid]]s that commonly co-purify with peptidoglycan. Also variation in peptidoglycan structure in bacteria from species to species may contribute to the differing results on this topic.<ref name="Wolf-2018" /><ref name="Bastos-2021" />