Editing Pentamidine (section)

==Side effects==

=== Common ===
* Burning pain, dryness, or sensation of lump in throat
* Chest pain
* Coughing
* difficulty in breathing
* difficulty in swallowing
* skin rash
* wheezing<ref name=":4">{{Cite web|url=https://www.drugs.com/sfx/pentamidine-side-effects.html|title=Pentamidine Side Effects in Detail - Drugs.com|website=www.drugs.com|access-date=2016-11-04|url-status=live|archive-url=https://web.archive.org/web/20161104142210/https://www.drugs.com/sfx/pentamidine-side-effects.html|archive-date=2016-11-04}}</ref>

=== Rare ===
* Nausea and vomiting
* Pain in upper abdomen, possibly radiating to the back
* Severe pain in side of chest
* Shortness of breath<ref name=":4" />

=== Others ===
* [[Blood]]: Pentamidine frequently causes [[leukopenia]] and less often [[thrombopenia]], which may cause symptomatic bleeding. Some cases of [[anemia]], possibly related to [[folic acid]] deficiency, have been described.<ref name=":4" />
* [[Cardiovascular system|Cardiovascular]]: [[Hypotension]], which may be severe. Severe or fatal [[Heart arrhythmia|arrhythmia]]s and [[heart failure]] are quite frequent.<ref name=":10" />
* [[Kidney]]: 25 percent develop signs of [[nephrotoxicity]] ranging from mild, asymptomatic [[azotemia]] (increased serum [[creatinine]] and [[urea]]) to irreversible [[renal failure]]. Ample fluids or intravenous hydration may prevent some nephrotoxicity.<ref name=":10" />
* [[Liver]]: Elevated [[liver enzymes]] are associated with intravenous use of pentamidine. [[Hepatomegaly]] and [[hepatitis]] have been encountered with long term prophylactic use of pentamidine inhalation.<ref name=":10" />
* [[Nervous system|Neurological]]:  Dizziness, drowsiness, [[neuralgia]], confusion, hallucinations, [[seizure]]s and other central side effects are reported.<ref name=":10" />
* [[Pancreas]]: [[Hypoglycemia]] that requires symptomatic treatment is frequently seen. On the other hand, pentamidine may cause or worsen [[diabetes mellitus]].<ref name=":10" />
* [[Respiratory system|Respiratory]]: Cough and [[bronchospasm]], most frequently seen with inhalation.<ref name=":10" />
* [[Skin]]: Severe local reactions after extravasculation of intravenous solutions or following intramuscular injection treatment have been seen. Pentamidine itself may cause rash, or rarely [[Stevens–Johnson syndrome]] or [[Toxic epidermal necrolysis|Lyell syndrome]].<ref name=":10" />
* Eye discomfort, [[conjunctivitis]], throat irritation, [[splenomegaly]], [[Herxheimer reaction]], [[electrolyte]] imbalances (e.g. [[hypocalcemia]]).<ref name=":10" />