Editing Nuclear pore complex (section)

===Preservation of integrity===
In [[fungi]] undergoing [[Mitosis|closed mitosis]], where the nucleus remains intact, changes in the permeability barrier of the nuclear envelope are attributed to alterations within the NPC. These changes facilitate the entry of mitotic regulators into the nucleus. Studies in ''Aspergillys nidulans'' suggest that the NPC composition appears to be effected by the mitotiv kinase NIMA. NIMA potentially phosphorylates nucleoporins Nup98 and Gle2/Rae1, leading to NPC remodeling.<ref>{{cite journal |last1=Liu |first1=Hui-Lin |last2=De Souza |first2=Colin P.C. |last3=Osmani |first3=Aysha H. |last4=Osmani |first4=Stephen A. |title=The Three Fungal Transmembrane Nuclear Pore Complex Proteins of Aspergillus nidulans Are Dispensable in the Presence of an Intact An-Nup84-120 Complex |journal=Molecular Biology of the Cell |date=15 January 2009 |volume=20 |issue=2 |pages=616–630 |doi=10.1091/mbc.e08-06-0628 |pmid=19019988 |pmc=2626566 }}</ref> This remodeling allows the nuclear entry of the protein complex cdc2/cyclinB and various other proteins, including soluble tubulin. The NPC scaffold remains intact throughout the whole closed mitosis. This seems to preserve the integrity of the nuclear envelope.<ref>{{cite journal |last1=Kutay |first1=Ulrike |last2=Jühlen |first2=Ramona |last3=Antonin |first3=Wolfram |title=Mitotic disassembly and reassembly of nuclear pore complexes |journal=Trends in Cell Biology |date=December 2021 |volume=31 |issue=12 |pages=1019–1033 |doi=10.1016/j.tcb.2021.06.011 |pmid=34294532 |hdl=20.500.11850/518955 |hdl-access=free }}</ref>