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=== Unintended bias === Some studies suggests that inadequate published data in animal testing may result in irreproducible research, with missing details about how experiments are done omitted from published papers or differences in testing that may introduce bias. Examples of hidden bias include a 2014 study from [[McGill University]] in [[Montreal|Montreal, Canada]] which suggests that mice handled by men rather than women showed higher stress levels.<ref>{{cite news|url=https://www.economist.com/news/christmas-specials/21712058-evolution-scientific-mainstay-worlds-favourite-lab-animal-has-been-found|title=The world's favourite lab animal has been found wanting, but there are new twists in the mouse's tale|newspaper=The Economist|access-date=2017-01-10}}</ref><ref>{{cite journal |last1=Katsnelson |first1=Alla |title=Male researchers stress out rodents |journal=Nature |date=2014-04-28 |pages=nature.2014.15106 |doi=10.1038/nature.2014.15106 |doi-access=free }}</ref><ref>{{Cite news|url=https://www.science.org/content/article/male-scent-may-compromise-biomedical-research|title=Male Scent May Compromise Biomedical Research|date=2014-04-28|newspaper=Science {{!}} AAAS|access-date=2017-01-10}}</ref> Another study in 2016 suggested that gut [[Microbiota|microbiomes]] in mice may have an impact upon scientific research.<ref>{{Cite news|url=https://www.science.org/content/article/mouse-microbes-may-make-scientific-studies-harder-replicate|title=Mouse microbes may make scientific studies harder to replicate|date=2016-08-15|newspaper=Science {{!}} AAAS|access-date=2017-01-10}}</ref>
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