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==Silk== {{More citations needed|date=January 2022}} The [[silk]] [[fibroin]]s produced by [[insect]]s and [[spider]]s are often classified as keratins, though it is unclear whether they are phylogenetically related to vertebrate keratins. Silk found in insect [[pupa]]e, and in [[spider web]]s and egg casings, also has twisted β-pleated sheets incorporated into fibers wound into larger supermolecular aggregates. The structure of the [[spinneret (spider)|spinneret]]s on spiders' tails, and the contributions of their interior [[gland]]s, provide remarkable control of fast [[extrusion]]. Spider silk is typically about 1 to 2 micrometers (μm) thick, compared with about 60 μm for human hair, and more for some mammals. The [[biology|biologically]] and [[commerce|commercially]] useful properties of [[spider silk#Properties|silk fibers]] depend on the organization of multiple adjacent protein chains into hard, [[crystal]]line regions of varying size, alternating with flexible, [[amorphous]] regions where the chains are [[random coil|randomly coiled]].<ref>{{cite web | vauthors = Australia | title = Spiders – Silk structure | url = http://www.amonline.net.au/spiders/toolkit/silk/structure.htm | publisher = Amonline.net.au | access-date = 2010-09-23 | url-status = dead | archive-url = https://web.archive.org/web/20090508161836/http://www.amonline.net.au/spiders/toolkit/silk/structure.htm | archive-date = 2009-05-08 }}</ref> A somewhat analogous situation occurs with [[chemical synthesis|synthetic]] [[polymer]]s such as [[nylon]], developed as a silk substitute. Silk from the [[hornet]] [[Silkworm cocoons|cocoon]] contains doublets about 10 μm across, with cores and coating, and may be arranged in up to 10 layers, also in plaques of variable shape. Adult hornets also use silk as a [[adhesive|glue]], as do spiders.
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