Editing Intracytoplasmic sperm injection (section)

==Complications==
{{See also|In vitro fertilisation#Complications}}

There is some suggestion that [[birth defects]] are increased with the use of IVF in general, and ICSI specifically, though different studies show contradictory results. In a summary position paper, the Practice Committee of the American Society of Reproductive Medicine has said it considers ICSI safe and effective therapy for male factor infertility, but may carry an increased risk for the transmission of selected genetic abnormalities to offspring, either through the procedure itself or through the increased inherent risk of such abnormalities in parents undergoing the procedure.<ref>{{cite journal | vauthors =  ((Practice Committee of the American Society for Reproductive Medicine)), ((Practice Committee of the Society for Assisted Reproductive Technology)) | title = Genetic considerations related to intracytoplasmic sperm injection (ICSI) | journal = Fertility and Sterility | volume = 86 | issue = 5 Suppl 1 | pages = S103–S105 | date = November 2006 | pmid = 17055799 | doi = 10.1016/j.fertnstert.2006.07.1489 | doi-access = free }}</ref>

There is not enough evidence to say that ICSI procedures are safe in females with [[hepatitis B]] in regard to vertical transmission to the offspring, since the puncture of the oocyte can potentially avail for [[vertical transmission]] to the offspring.<ref name=Lutgens2009>{{cite journal | vauthors = Lutgens SP, Nelissen EC, van Loo IH, Koek GH, Derhaag JG, Dunselman GA | title = To do or not to do: IVF and ICSI in chronic hepatitis B virus carriers | journal = Human Reproduction | volume = 24 | issue = 11 | pages = 2676–2678 | date = November 2009 | pmid = 19625309 | doi = 10.1093/humrep/dep258 | doi-access = free }}</ref>