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===Cytomegalovirus=== {{Main|Human betaherpesvirus 5}} About 5β7% of cases of infectious mononucleosis is caused by [[human cytomegalovirus]] (CMV), another type of [[Herpesviridae|herpes virus]].<ref name="pmid27933614">{{cite journal | vauthors=De Paor M, O'Brien K, Smith SM | title=Antiviral agents for infectious mononucleosis (glandular fever) | journal=[[Cochrane Library#The Cochrane Database of Systematic Reviews|The Cochrane Database of Systematic Reviews]] | volume=2016 | issue=12 | pages=CD011487 | year=2016 | doi = 10.1002/14651858.CD011487.pub2 | pmc=6463965 | pmid=27933614}}</ref> This virus is found in body fluids including [[saliva]], [[urine]], [[blood]], [[tears]],<ref name="STD Sourcebook">Larsen, Laura. ''Sexually Transmitted Diseases Sourcebook. Health Reference Series Detroit'': Omnigraphics, Inc., 2009. Online.</ref> [[breast milk]] and genital secretions.<ref name=frontiersCMV2006/> A person becomes infected with this [[virus]] by direct contact with infected body fluids. Cytomegalovirus is most commonly transmitted through kissing and sexual intercourse. It can also be transferred from an infected mother to her unborn child. This virus is often "silent" because the signs and symptoms cannot be felt by the person infected.<ref name="STD Sourcebook"/> However, it can cause life-threatening illness in infants, people with [[HIV]], [[Organ transplant|transplant]] recipients, and those with weak [[immune systems]]. For those with weak immune systems, cytomegalovirus can cause more serious illnesses such as [[pneumonia]] and inflammations of the [[retina]], [[esophagus]], [[liver]], [[large intestine]], and [[brain]]. Approximately 90% of the human population has been infected with cytomegalovirus by the time they reach adulthood, but most are unaware of the infection.<ref>Carson-DeWitt and Teresa G. ''The Gale Encyclopedia of Medicine.'' Vol. 2. 3rd ed. Detroit: Gale, 2006.</ref> Once a person becomes infected with cytomegalovirus, the virus stays in their body throughout the person's lifetime. During this latent phase, the virus can be detected only in [[monocytes]].<ref name=frontiersCMV2006>{{cite journal |last1=Forte |first1=Eleonora |last2=Zhang |first2=Zheng |last3=Thorp |first3=Edward B. |last4=Hummel |first4=Mary |title=Cytomegalovirus Latency and Reactivation: An Intricate Interplay With the Host Immune Response |journal=Frontiers in Cellular and Infection Microbiology |date=31 March 2020 |volume=10 |page=130 |doi=10.3389/fcimb.2020.00130|doi-access=free|pmid=32296651 |pmc=7136410 }}</ref>
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