Editing Huntington's disease (section)

===Transcriptional dysregulation===

[[CREB-binding protein]] (CBP), a transcriptional coregulator, is essential for cell function because as a coactivator at a significant number of promoters, it activates the transcription of genes for survival pathways.<ref name="urlNature Clinical Practice Neurology | Mechanisms of Disease: histone modifications in Huntingtons disease | Article"/> CBP contains an [[acetyltransferase]] domain to which HTT binds through its polyglutamine-containing domain.<ref>{{cite journal | vauthors = Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM | title = Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila | journal = Nature | volume = 413 | issue = 6857 | pages = 739–743 | date = October 2001 | pmid = 11607033 | doi = 10.1038/35099568 | s2cid = 4419980 | bibcode = 2001Natur.413..739S | url = https://escholarship.org/uc/item/5q52298v | access-date = 28 June 2019 | archive-date = 1 August 2020 | archive-url = https://web.archive.org/web/20200801220516/https://escholarship.org/uc/item/5q52298v | url-status = live }}</ref> Autopsied brains of those who had Huntington's disease also have been found to have incredibly reduced amounts of CBP.<ref name="urlAnalysis of Strand Slippage in DNA Polymerase Expansions of CAG/CTG Triplet Repeats Associated with Neurodegenerative Disease – JBC">{{cite journal | vauthors = Petruska J, Hartenstine MJ, Goodman MF | title = Analysis of strand slippage in DNA polymerase expansions of CAG/CTG triplet repeats associated with neurodegenerative disease | journal = The Journal of Biological Chemistry | volume = 273 | issue = 9 | pages = 5204–5210 | date = February 1998 | pmid = 9478975 | doi = 10.1074/jbc.273.9.5204 | doi-access = free }}</ref> In addition, when CBP is overexpressed, polyglutamine-induced death is diminished, further demonstrating that CBP plays an important role in Huntington's disease and neurons in general.<ref name="urlNature Clinical Practice Neurology | Mechanisms of Disease: histone modifications in Huntingtons disease | Article"/>