Editing Human skin color (section)

==== KITLG ====
[[File:KITLG (rs1881227).png|thumb|KITLG (rs1881227)]]
The [[KIT ligand]] (KITLG) gene is involved in the permanent survival, proliferation and migration of melanocytes.<ref name="pmid12753403">{{cite journal |last1=Wehrle-Haller |first1=Bernhard |title=The Role of Kit-Ligand in Melanocyte Development and Epidermal Homeostasis |journal=Pigment Cell Research |volume=16 |issue=3 |pages=287–96 |year=2003 |pmid=12753403 |doi=10.1034/j.1600-0749.2003.00055.x}}</ref> A mutation in this gene, ''A326G'' (rs642742<ref>[https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=642742 Reference SNP(refSNP) Cluster Report: rs642742 **clinically associated**] {{webarchive|url= https://web.archive.org/web/20180328071821/https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=642742 |date=2018-03-28 }}. Ncbi.nlm.nih.gov (2008-12-30). Retrieved 2011-02-27.</ref>), has been positively associated with variations of skin color in African-Americans of mixed West African and European descent and is estimated to account for 15–20% of the melanin difference between African and European populations.<ref name=Miller2007>{{cite journal |last1=Miller |first1=Craig T. |last2=Beleza |first2=Sandra |last3=Pollen |first3=Alex A. |last4=Schluter |first4=Dolph |last5=Kittles |first5=Rick A. |last6=Shriver |first6=Mark D. |last7=Kingsley |first7=David M. |title=cis-Regulatory Changes in Kit Ligand Expression and Parallel Evolution of Pigmentation in Sticklebacks and Humans |journal=Cell |volume=131 |issue=6 |pages=1179–89 |year=2007 |pmid=18083106 |pmc=2900316 |doi=10.1016/j.cell.2007.10.055}}</ref><ref name=Pickrell2009>{{cite journal |title=Signals of recent positive selection in a worldwide sample of human populations |journal=Genome Research |year=2009 |volume=19 |pages=826–837 |doi=10.1101/gr.087577.108 |issue=5 |pmid=19307593 |pmc=2675971 |last1=Pickrell |first1=J. K. |last2=Coop |first2=G |last3=Novembre |first3=J |last4=Kudaravalli |first4=S |last5=Li |first5=J. Z. |last6=Absher |first6=D |last7=Srinivasan |first7=B. S. |last8=Barsh |first8=G. S. |last9=Myers |first9=R. M. |last10=Feldman |first10=M. W. |last11=Pritchard |first11=J. K. }}</ref> and occurs in over 80% of European and Asian samples, compared with less than 10% in African samples.<ref name=Miller2007 />