Editing Hexokinase (section)

==Association with mitochondria==
Hexokinases I and II can associate physically to the outer surface of the external membrane of [[mitochondria]] through specific binding to a porin, or voltage dependent anion channel. This association confers hexokinase direct access to ATP generated by mitochondria, which is one of the two substrates of hexokinase. Mitochondrial hexokinase is highly elevated in rapidly growing malignant tumor cells, with levels up to 200 times higher than normal tissues. Mitochondrially bound hexokinase has been demonstrated to be the driving force<ref>{{cite journal |vauthors=Bustamante E, Pedersen P |title=High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase |journal= Proceedings of the National Academy of Sciences |volume=74 |issue=9 |pages=3735–9 |year=1977 |pmid=198801 |doi=10.1073/pnas.74.9.3735 |pmc=431708 |bibcode=1977PNAS...74.3735B|doi-access=free }}</ref> for the extremely high glycolytic rates that take place aerobically in tumor cells (the so-called Warburg effect described by [[Otto Heinrich Warburg]] in 1930).