Editing Glutamine (section)

== Safety ==
Glutamine is safe in adults and in preterm infants.<ref name="pmid11533313">{{cite journal | vauthors = Garlick PJ | title = Assessment of the safety of glutamine and other amino acids | journal = The Journal of Nutrition | volume = 131 | issue = 9 Suppl | pages = 2556S–2561S | date = September 2001 | pmid = 11533313 | doi = 10.1093/jn/131.9.2556S | doi-access = free }}</ref> Although glutamine is metabolized to glutamate and ammonia, both of which have neurological effects, their concentrations are not increased much, and no adverse neurological effects were detected.<ref name="pmid11533313"/> The observed safe level for supplemental <small>L</small>-glutamine in normal healthy adults is 14 g/day.<ref name="pmid18325648">{{cite journal | vauthors = Shao A, Hathcock JN | title = Risk assessment for the amino acids taurine, L-glutamine and L-arginine | journal = Regulatory Toxicology and Pharmacology | volume = 50 | issue = 3 | pages = 376–399 | date = April 2008 | pmid = 18325648 | doi = 10.1016/j.yrtph.2008.01.004 }}</ref>

Adverse effects of glutamine have been described for people receiving home parenteral nutrition and those with liver-function abnormalities.<ref name="pmid11451714">{{cite journal | vauthors = Buchman AL | title = Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data | journal = The American Journal of Clinical Nutrition | volume = 74 | issue = 1 | pages = 25–32 | date = July 2001 | pmid = 11451714 | doi = 10.1093/ajcn/74.1.25 | doi-access = free }}</ref>
Although glutamine has no effect on the proliferation of tumor cells, it is still possible that glutamine supplementation may be detrimental in some cancer types.<ref name="pmid22990615">{{cite journal | vauthors = Holecek M | title = Side effects of long-term glutamine supplementation | journal = Journal of Parenteral and Enteral Nutrition | volume = 37 | issue = 5 | pages = 607–616 | date = September 2013 | pmid = 22990615 | doi = 10.1177/0148607112460682 }}</ref>

Ceasing glutamine supplementation in people adapted to very high consumption may initiate a withdrawal effect, raising the risk of health problems such as infections or impaired integrity of the intestine.<ref name="pmid22990615"/>