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===Medications=== The [[PDE5 inhibitor]]s [[sildenafil]] (Viagra), [[vardenafil]] (Levitra) and [[tadalafil]] (Cialis) are prescription drugs which are taken by mouth.<ref name=EuroGuideline/>{{rp|20β21}} As of 2018, sildenafil is available in the UK without a prescription.<ref>{{cite news |url=https://www.bbc.com/news/health-42155489 |title=Viagra can be sold over the counter |date=28 November 2017 |work=BBC News |access-date=5 April 2018 |archive-date=22 February 2021 |archive-url=https://web.archive.org/web/20210222234502/https://www.bbc.com/news/health-42155489 |url-status=live }}</ref> Additionally, a cream combining [[alprostadil]] with the permeation enhancer [[DDAIP]] has been approved in Canada as a [[First-line treatment|first line treatment]] for ED.<ref>{{cite web|vauthors=Bujdos B|title=New Topical Erectile Dysfunction Drug Vitaros Approved in Canada; Approved Topical Drug Testim Proves Helpful for Erectile Dysfunction|date=16 November 2010|url=http://www.accessrx.com/blog/current-health-news/vitaros-testim-topical-drugs-treat-erectile-dysfunction-a1115|access-date=15 April 2011|archive-date=13 May 2011|archive-url=https://web.archive.org/web/20110513011529/http://www.accessrx.com/blog/current-health-news/vitaros-testim-topical-drugs-treat-erectile-dysfunction-a1115|url-status=live}}</ref> Penile injections, on the other hand, can involve one of the following medications: [[papaverine]], [[phentolamine]], and [[prostaglandin E1]], also known as [[alprostadil]].<ref name=EuroGuideline/> In addition to injections, there is an alprostadil [[suppository]] that can be inserted into the urethra. Once inserted, an erection can begin within 10 minutes and last up to an hour.<ref name=":0">{{Cite web|url=https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/treatment|title=Treatment for erectile dysfunction {{!}}|website=US National Institute of Diabetes and Digestive and Kidney Diseases|language=en-US|access-date=2019-08-04|archive-date=2021-02-22|archive-url=https://web.archive.org/web/20210222234446/https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/treatment|url-status=live}}</ref> Medications to treat ED may cause a side effect called [[priapism]].<ref name=":0" /> ====Prevalence of medical diagnosis==== In a study published in 2016, based on US health insurance claims data, out of 19,833,939 US males aged β₯18 years, only 1,108,842 (5.6%), were medically diagnosed with erectile dysfunction or on a PDE5I prescription (''ΞΌ'' age 55.2 years, ''Ο'' 11.2 years). Prevalence of diagnosis or prescription was the highest for age group 60β69 at 11.5%, lowest for age group 18β29 at 0.4%, and 2.1% for 30β39, 5.7% for 40β49, 10% for 50β59, 11% for 70β79, 4.6% for 80β89, 0.9% for β₯90, respectively.<ref name="US study">{{cite journal | vauthors = Mulhall JP, Luo X, Zou KH, Stecher V, Galaznik A | title = Relationship between age and erectile dysfunction diagnosis or treatment using real-world observational data in the USA | journal = International Journal of Clinical Practice | volume = 70 | issue = 12 | pages = 1012β1018 | date = December 2016 | pmid = 28032424 | pmc = 5540144 | doi = 10.1111/ijcp.12908 }}</ref>
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