Editing Dehydroepiandrosterone (section)

====Other nuclear receptors====
DHEA does not bind to or activate the [[progesterone receptor|progesterone]], [[glucocorticoid receptor|glucocorticoid]], or [[mineralocorticoid receptor]]s.<ref name="pmid15994348" /><ref name="pmid21747041">{{cite journal | vauthors = Lindschau C, Kirsch T, Klinge U, Kolkhof P, Peters I, Fiebeler A | title = Dehydroepiandrosterone-induced phosphorylation and translocation of FoxO1 depend on the mineralocorticoid receptor | journal = Hypertension | volume = 58 | issue = 3 | pages = 471–8 | date = September 2011 | pmid = 21747041 | doi = 10.1161/HYPERTENSIONAHA.111.171280 | url = http://hyper.ahajournals.org/cgi/pmidlookup?view=long&pmid=21747041 | doi-access = free }}</ref> Other [[nuclear receptor]] targets of DHEA besides the androgen and estrogen receptors include the [[peroxisome proliferator-activated receptor|PPARα]], [[pregnane X receptor|PXR]], and [[constitutive androstane receptor|CAR]].<ref name="pmid26908835" /> However, whereas DHEA is a [[ligand (biochemistry)|ligand]] of the PPARα and PXR in rodents, it is not in humans.<ref name="Watson2011">{{cite book| first = Ronald Ross | last = Watson | name-list-style = vanc |title=DHEA in Human Health and Aging|url=https://books.google.com/books?id=pKXMBQAAQBAJ&pg=PA208|date=22 July 2011|publisher=CRC Press|isbn=978-1-4398-3884-6|pages=208–}}</ref> In addition to direct interactions, DHEA is thought to regulate a handful of other [[protein]]s via indirect, genomic mechanisms, including the [[enzyme]]s [[CYP2C11]] and [[11β-hydroxysteroid dehydrogenase type 1|11β-HSD1]] – the latter of which is essential for the biosynthesis of the [[glucocorticoid]]s such as [[cortisol]] and has been suggested to be involved in the [[antiglucocorticoid]] effects of DHEA – and the [[carrier protein]] [[Insulin-like growth factor-binding protein 1|IGFBP1]].<ref name="pmid15994348" /><ref name="pmid8035785">{{cite journal | vauthors = Kalimi M, Shafagoj Y, Loria R, Padgett D, Regelson W | title = Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA) | journal = Molecular and Cellular Biochemistry | volume = 131 | issue = 2 | pages = 99–104 | date = February 1994 | pmid = 8035785 | doi = 10.1007/BF00925945 | s2cid = 26893297 }}</ref>