Editing Cyclic nucleotide (section)

===Pathway mutations and related diseases===
Examples of disruptions of cNMP pathways include: mutations in CNG channel [[gene]]s are associated with degeneration of the retina and with [[color blindness]];<ref name=kaupp /> and [[gene expression|overexpression]] of cytosolic or [[soluble adenylyl cyclase]] (sAC) has been linked to human [[prostate cancer|prostate carcinoma]].  Inhibition of sAC, or knockdown by [[RNA interference]] (RNAi) [[transfection]] has been shown to prevent the [[cell growth|proliferation]] of the prostate carcinoma cells.  The regulatory pathway appears to be part of the EPAC pathway and not the PKA pathway.<ref name="Flacke" />

Phosphodiesterases, principle regulators of cNMP degradation, are often targets for therapeutics.  Caffeine is a known PDE inhibitor, while drugs used for the treatment of erectile dysfunction like [[sildenafil]] and [[tadalafil]] also act through inhibiting the activity of phosphodiesterases.<ref name="bender" />