Editing Cyclic adenosine monophosphate (section)

=== Role in prefrontal cortex disorders ===
Research suggests that cAMP affects the function of higher-order thinking in the [[prefrontal cortex]] through its regulation of ion channels called [[hyperpolarization-activated cyclic nucleotide-gated channels]] (HCN). HCN channels will open when exposed to cAMP. Once the HCN channel is open, the electrical activity within the neuron is disrupted and the cell becomes less responsive. This interferes with the function of the [[prefrontal cortex]] in working memory tasks. Inhibition of cAMP has been observed to improve spatial working memory.<ref>{{cite web| last1 = Arnsten| first1 = Amy| last2 = McCormick| first2 = David| title = Cyclic AMP, a molecule linked to stress, also plays a role in memory loss| date = 2007| url = https://medicine.yale.edu/news/yale-medicine-magazine/article/cyclic-amp-a-molecule-linked-to-stress-also/}}</ref><ref>{{cite journal| doi = 10.1016/j.cell.2007.03.015| issn = 00928674| volume = 129| issue = 2| pages = 397–410| last1 = Wang| first1 = Min| last2 = Ramos| first2 = Brian P.| last3 = Paspalas| first3 = Constantinos D.| last4 = Shu| first4 = Yousheng| last5 = Simen| first5 = Arthur| last6 = Duque| first6 = Alvaro| last7 = Vijayraghavan| first7 = Susheel| last8 = Brennan| first8 = Avis| last9 = Dudley| first9 = Anne| last10 = Nou| first10 = Eric| last11 = Mazer| first11 = James A.| last12 = McCormick| first12 = David A.| last13 = Arnsten| first13 = Amy F.T.| title = α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex| journal = Cell| access-date = 2025-03-03| date = April 2007 | url = https://linkinghub.elsevier.com/retrieve/pii/S0092867407003443}}</ref>

cAMP is involved in activation of trigeminocervical system leading to neurogenic inflammation and causing migraine. <ref>{{cite journal |last1=Segatto |first1=Marco |title=Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research |journal=Biomedicines |year=2021 |volume=10 |issue=1 |page=76 |doi=10.3390/biomedicines10010076 |pmid=35052756 |pmc=8773152 |doi-access=free }}</ref>