Editing Chlorpromazine (section)

===Pharmacokinetics===
{| class = wikitable
|+ <big>Pharmacokinetic parameters of chlorpromazine</big><ref name = TGA/><ref name = GG/><ref name=EMCS>{{cite web|title=Chlorpromazine Hydrochloride 100mg/5ml Oral Syrup – Summary of Product Characteristics (SPC)|work=electronic Medicines Compendium|publisher=Rosemont Pharmaceuticals Limited|date=6 August 2013|access-date=8 December 2013|url=http://www.medicines.org.uk/emc/medicine/10751/SPC/Chlorpromazine+Hydrochloride+100mg+5ml+Oral+Syrup/|url-status=live|archive-url=https://web.archive.org/web/20131211235858/http://www.medicines.org.uk/emc/medicine/10751/SPC/Chlorpromazine+Hydrochloride+100mg+5ml+Oral+Syrup/|archive-date=11 December 2013}}</ref>
! Bioavailability !! t<sub>max</sub> !! C<sub>SS</sub> !!  Protein bound !! V<sub>d</sub> !! t<sub>1/2</sub> !! Details of metabolism !! Excretion !! Notes
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| 10–80% || 1–4 hours (Oral); 6–24 hours (IM) || 100–300&nbsp;ng/mL || 90–99% || 10–35 L/kg (mean: 22 L/kg) || 30±7 hours || [[CYP2D6]], [[CYP1A2]]—mediated into over 10 major metabolites.<ref name = GG/> The major routes of metabolism include hydroxylation, N-oxidation, sulfoxidation, demethylation, deamination and conjugation. There is little evidence supporting the development of metabolic tolerance or an increase in the metabolism of chlorpromazine due to microsomal liver enzymes following multiple doses of the drug.<ref name="Dahl">{{cite journal | vauthors = Dahl SG, Strandjord RE | title = Pharmacokinetics of chlorpromazine after single and chronic dosage | journal = Clinical Pharmacology and Therapeutics | volume = 21 | issue = 4 | pages = 437–448 | date = April 1977 | pmid = 849674 | doi = 10.1002/cpt1977214437 | s2cid = 6645825 }}</ref> || Urine (43–65% after 24 hours) || Its high degree of [[lipophilicity]] (fat solubility) allows it to be detected in the urine for up to 18 months.<ref name =TGA/><ref name = "Yeu"/> Less than 1% of the unchanged drug is excreted via the kidneys in the urine, in which 20–70% is excreted as conjugated or unconjugated metabolites, whereas 5–6% is excreted in feces.<ref name="Yeu">{{cite journal | vauthors = Yeung PK, Hubbard JW, Korchinski ED, Midha KK | title = Pharmacokinetics of chlorpromazine and key metabolites | journal = European Journal of Clinical Pharmacology | volume = 45 | issue = 6 | pages = 563–569 | year = 1993 | pmid = 8157044 | doi = 10.1007/BF00315316 | s2cid = 6410850 }}</ref>
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[[Image:MetabsofChlorpromazine.svg|class=skin-invert-image|thumb|left|600px|Three common metabolites of chlorpromazine]]
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