Editing Breast cancer (section)

== Prognosis ==

Breast cancer prognosis varies widely depending on how far the tumor has spread at the time of diagnosis. Overall, 91% of women diagnosed with breast cancer [[Five-year survival rate|survive at least five years]] from diagnosis. Those whose tumor(s) are completely confined to the breast (nearly two thirds of cases) have the best prognoses – over 99% survive at least five years.<ref>{{cite web|url=https://seer.cancer.gov/statfacts/html/breast.html |accessdate=20 June 2024 |title=Cancer Stat Facts: Female Breast Cancer |publisher=National Cancer Institute |date=2024}}</ref> Those whose tumors have metastasized to distant sites have relatively poor prognoses – 31% survive at least five years from the time of diagnosis.<ref>{{cite web|url=https://www.cancer.org/cancer/types/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-survival-rates.html |accessdate=20 June 2024 |title=Survival Rates for Breast Cancer |publisher=American Cancer Society |date=17 January 2024}}</ref> Triple-negative breast cancer (up to 15% of cases) and inflammatory breast cancer (up to 5% of cases) are particularly aggressive and have relatively poor prognoses.<ref name=ACS-TNBC>{{cite web|url=https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/triple-negative.html |accessdate=20 June 2024 |title=Triple-Negative Breast Cancer |publisher=American Cancer Society |date=1 March 2023}}</ref><ref name=ACS-IBC>{{cite web|url=https://www.cancer.org/cancer/types/breast-cancer/about/types-of-breast-cancer/inflammatory-breast-cancer.html |accessdate=20 June 2024 |title=Inflammatory Breast Cancer |publisher=American Cancer Society |date=1 March 2023}}</ref> Those with triple-negative breast cancer have an overall five-year survival rate of 77% – 91% for those whose tumors are confined to the breast; 12% for those with metastases.<ref name=ACS-TNBC/> Those with inflammatory breast cancer are diagnosed after the cancer has already spread to the skin of the breast. They have an overall five-year survival rate of 39%; 19% for those with metastases.<ref name=ACS-IBC/> The relatively rare tumors with tubular, mucinous, or medullary growth tend to have better prognoses.{{sfn|Hayes|Lippman|2022|loc="Prognostic Factors"}}

In addition to the factors that influence cancer staging, a person's age can also impact prognosis. Breast cancer before age 35 is rare, and is more likely to be associated with genetic predisposition to aggressive cancer. Conversely, breast cancer in those aged over 75 is associated with poorer prognosis.{{sfn|Harbeck|Penault-Llorca|Cortes|Gnant|2019|loc="Prognosis"}}