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=== Traditional medicine === Products made from margosa trees have been used in the [[traditional medicine]] of India for centuries,<ref name="bbc.co.uk"/><ref name="drugs">{{cite web|url=https://www.drugs.com/npp/neem.html |title=Neem |publisher=Drugs.com |access-date=21 September 2020 |date=13 August 2020}}</ref> for treating skin troubles and [[rheumatism]],<ref>{{cite journal |last1=Tejesvi |first1=M.V. |last2=Tamhankar |first2=S.A. |last3=Kini |first3=K.R |last4=Rao |first4=V.S. |last5=Prakash |first5=H.S. |title=Phylogenetic analysis of endophytic ''Pestalotiopsis'' species from ethnopharmaceutically important medicinal trees. |journal=Fungal Diversity |date=2009 |volume=38 |pages=167β183}}</ref> but there is [[evidence-based medicine|insufficient clinical evidence]] to indicate any benefits of using margosa for medicinal purposes.<ref name=drugs/> In adults, no specific doses have been established, and short-term use of margosa appears to be safe, while long-term use may harm the [[kidney]]s or [[liver]]; in small children, margosa oil is toxic and can lead to death.<ref name=drugs/> Margosa may also cause [[miscarriage]]s, [[infertility]], and [[Hypoglycemia|low blood sugar]].<ref name=drugs/> In Southern India and the Middle-East, neem twigs are often used as a [[teeth-cleaning twig]].<ref name="dentalmuseum.pacific.edu">{{Cite web|title=Different Strokes for Different Folks: A History of the Toothbrush β Page 4 β Virtual Dental Museum|url=https://dentalmuseum.pacific.edu/different-strokes-different-folks-history-toothbrush/4/|access-date=2021-07-08|website=dentalmuseum.pacific.edu}}</ref>
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