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===Medication=== * [[Salicylic acid]] can be prescribed by a dermatologist in a higher concentration than that found in over-the-counter products. Several [[over-the-counter drug|over-the-counter]] products are readily available at [[pharmacies]] and supermarkets of roughly two types: adhesive pads treated with salicylic acid, and bottled concentrated salicylic acid and [[lactic acid]] solution. * [[Fluorouracil]] β Fluorouracil cream, a [[chemotherapy]] agent sometimes used to treat [[skin cancer]], can be used on particularly resistant warts, by blocking [[Virus|viral]] [[DNA]] and [[RNA]] production and repair.<ref>{{cite journal |last1=Salk |first1=RS |last2=Grogan |first2=KA |last3=Chang |first3=TJ |date=May 2006 |title=Topical 5% 5-fluorouracil cream in the treatment of plantar warts: a prospective, randomized, and controlled clinical study. |url=https://jddonline.com/articles/dermatology/S1545961606P0418X |journal=[[Journal of Drugs in Dermatology]] |volume=5 |issue=5 |pages=418β24 |pmid=16703777}}</ref> * [[Imiquimod]] is a [[topical cream]] that helps the body's [[immune system]] fight the wart virus by encouraging [[interferon]] production. It has been approved by the [[U.S. Food and Drug Administration]] (FDA) for genital warts.<ref>{{cite web |date=4 June 2011 |title=Short-Acting Imiquimod Cream Approved for Genital Warts |url=http://www.medscape.org/viewarticle/740315 |url-status=live |archive-url=https://web.archive.org/web/20110818095949/http://www.medscape.org/viewarticle/740315 |archive-date=18 August 2011 |access-date=10 August 2011 |work=[[Medscape]] |vauthors=Barclay L}}</ref> * [[Cantharidin]], found naturally in the bodies of many members of the [[beetle]] family [[Meloidae]], causes dermal blistering. It is used either by itself or compounded with [[podophyllin]]. Not FDA approved, but available through [[Canada]] or select [[United States|US]] [[compounding pharmacies]]. * [[Bleomycin]] β A more potent chemotherapy drug, can be injected into deep warts, destroying the viral DNA or RNA. Bleomycin is notably not US [[FDA]] approved for this purpose. Possible side effects include [[necrosis]] of the digits, nail loss and [[Raynaud syndrome]]. The usual treatment is one or two injections.<ref>{{cite journal |last1=Soni |first1=Prasoon |last2=Khandelwal |first2=Kanika |last3=Aara |first3=Naushin |last4=Ghiya |first4=Bhikam C |last5=Mehta |first5=Rajesh D |last6=Bumb |first6=Ram A |date=2011 |title=Efficacy of Intralesional Bleomycin in Palmo-plantar and Periungual Warts |journal=[[Journal of Cutaneous and Aesthetic Surgery]] |volume=4 |issue=3 |pages=188β191 |doi=10.4103/0974-2077.91250 |pmc=3263129 |pmid=22279384 |doi-access=free }}</ref><ref>Champion, R. H., et al. (1998). ''[[Rook's Textbook of Dermatology]]''. [[Blackwell Science]], p. 1044, {{ISBN|0-632-06429-3}}</ref> * [[Dinitrochlorobenzene]] (DNCB), like [[salicylic acid]], is applied directly to the wart. Studies show this method is effective with a cure rate of 80%.{{medcn|date=August 2017}} But DNCB must be used much more cautiously than salicylic acid; the chemical is known to cause [[genetic mutations]], so it must be administered by a physician. This drug induces an allergic immune response, resulting in [[inflammation]] that wards off the wart-causing virus.<ref>{{cite web |date=31 August 2002 |title=Treating Warts |url=http://www.health.harvard.edu/fhg/updates/update0303d.shtml |url-status=dead |archive-url=https://web.archive.org/web/20101103023520/http://www.health.harvard.edu/fhg/updates/update0303d.shtml |archive-date=3 November 2010 |access-date=17 May 2013 |publisher=[[British Medical Journal]]}}</ref> * [[Cidofovir]] is an [[antiviral drug]] which is injected into HPV [[lesion]]s within the [[larynx]] ([[laryngeal papillomatosis]]) as an [[experimental treatment]].<ref name="SomaAlbert2008">{{cite journal |last1=Soma |first1=Marlene A |last2=Albert |first2=David M |year=2008 |title=Cidofovir: to use or not to use? |journal=[[Current Opinion in Otolaryngology & Head and Neck Surgery]] |volume=16 |issue=1 |pages=86β90 |doi=10.1097/MOO.0b013e3282f43408 |pmid=18197029 |s2cid=22895067}}</ref> * Verrutop verruca treatment is a topical solution made from a combination of [[organic acid]]s, [[Inorganic Acids|inorganic acids]], and [[metal ions]]. This solution causes the production of [[nitrite]]s, which act to denature [[viral protein]]s and mummify the wart tissue. The difference between Verrutop and other acid treatments is that it does not damage the surrounding skin. * Another product available over-the-counter that can aid in wart removal is [[silver nitrate]] in the form of a [[caustic pencil]], which is also available at drug stores. In a placebo-controlled study of 70 patients, silver nitrate given over nine days resulted in clearance of all warts in 43% and improvement in warts in 26% one month after treatment compared to 11% and 14%, respectively, in the placebo group.<ref>{{cite journal |vauthors=Sterling JC, Handfield-Jones S, Hudson PM |year=2001 |title=Guidelines for the management of cutaneous warts |url=http://www.huidziekten.nl/richtlijnen/BADguidelineCutaneousWarts2001.pdf |url-status=dead |journal=[[British Journal of Dermatology]] |volume=144 |issue=1 |pages=4β11 |doi=10.1046/j.1365-2133.2001.04066.x |pmid=11167676 |archive-url=https://web.archive.org/web/20120303031317/http://www.huidziekten.nl/richtlijnen/BADguidelineCutaneousWarts2001.pdf |archive-date=3 March 2012 |s2cid=20179474}}</ref> The instructions must be followed to minimize staining of skin and clothing. Occasionally, pigmented scars may develop. * [[Trichloroacetic acid]] can be used to treat warts if salicylic acid or cryotherapy fail or are not available. It requires repeat treatments every week or so. Side effects are burning and stinging.<ref>{{cite web |title=Common warts - Diagnosis and treatment - Mayo Clinic |url=https://www.mayoclinic.org/diseases-conditions/common-warts/diagnosis-treatment/drc-20371131 |website=www.mayoclinic.org |access-date=6 November 2022}}</ref> <gallery widths="200px" heights="200px"> Image:Wart ASA animated.gif|Two [[virus (biology)|viral]] warts on a middle finger, being treated with a mixture of acids (like salicylic acid) to remove them. A white precipitate forms on the area where the product was applied. File:A Throat After CO2 Laser Treatment of HPV6 Throat Papiloma (Warts).jpg|Throat warts before and after carbon dioxide laser treatment. </gallery>
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