Editing Tetracycline (section)

===Mechanisms of resistance===
Bacteria usually acquire resistance to tetracycline from [[horizontal gene transfer|horizontal transfer]] of a [[gene]] that either encodes an [[efflux pump]] or a ribosomal protection protein. Efflux pumps actively eject tetracycline from the cell, preventing the build up of an inhibitory concentration of tetracycline in the [[cytoplasm]].<ref>{{Cite journal |vauthors=Chopra I, Roberts M |date=June 2001 |title=Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance |journal=Microbiology and Molecular Biology Reviews |volume=65 |issue=2 |pages=232–60 ; second page, table of contents |doi=10.1128/MMBR.65.2.232-260.2001 |pmc=99026 |pmid=11381101}}</ref>  Ribosomal protection proteins interact with the ribosome and dislodge tetracycline from the ribosome, allowing for translation to continue.<ref>{{Cite journal |vauthors=Connell SR, Tracz DM, Nierhaus KH, Taylor DE |date=December 2003 |title=Ribosomal protection proteins and their mechanism of tetracycline resistance |journal=Antimicrobial Agents and Chemotherapy |volume=47 |issue=12 |pages=3675–3681 |doi=10.1128/AAC.47.12.3675-3681.2003 |pmc=296194 |pmid=14638464}}</ref>