Editing Retrovirus (section)

==Gene therapy==
[[Gammaretrovirus|Gammaretroviral]] and [[lentiviral]] [[Vector (molecular biology)|vectors]] for [[gene therapy]] have been developed that mediate stable genetic modification of treated cells by chromosomal integration of the transferred vector genomes. This technology is of use, not only for research purposes, but also for clinical gene therapy aiming at the long-term correction of genetic defects, e.g., in stem and progenitor cells. Retroviral vector particles with tropism for various target cells have been designed. Gammaretroviral and lentiviral vectors have so far been used in more than 300 clinical trials, addressing treatment options for various diseases.<ref name="KurthBannert"/><ref name= Desportm>{{Cite book | veditors = Desport M | year=2010 |title=Lentiviruses and Macrophages: Molecular and Cellular Interactions | publisher=Caister Academic | isbn= 978-1-904455-60-8}}</ref> Retroviral mutations can be developed to make transgenic mouse models to study various cancers and their [[Mouse models of breast cancer metastasis|metastatic models]].{{citation needed|date=November 2022}}