Editing Psilocybin (section)

====Theory of mind network and default mode network====
Psychedelics, including psilocybin, have been shown to affect different clusters of brain regions known as the "theory of mind network" (ToMN) and the [[default mode network]] (DMN).<ref name=":0">{{cite journal | vauthors = Soares C, Gonzalo G, Castelhano J, Castelo-Branco M | title = The relationship between the default mode network and the theory of mind network as revealed by psychedelics - A meta-analysis | journal = Neuroscience and Biobehavioral Reviews | volume = 152 | pages = 105325 | date = September 2023 | pmid = 37467907 | doi = 10.1016/j.neubiorev.2023.105325 | doi-access = free }}</ref> The ToMN involves making inferences and understanding social situations based on patterns<ref>{{cite journal | vauthors = Theriault J, Waytz A, Heiphetz L, Young L | title = Theory of mind network activity is associated with metaethical judgment: An item analysis | journal = Neuropsychologia | volume = 143 | pages = 107475 | date = June 2020 | pmid = 32360298 | doi = 10.1016/j.neuropsychologia.2020.107475 }}</ref> whereas, the DMN relates more to introspection and one's sense of self.<ref name=":0" /> The DMN in particular is related to increased rumination and worsening self-image in patients with major depressive disorder (MDD).<ref>{{cite journal | vauthors = Chou T, Deckersbach T, Dougherty DD, Hooley JM | title = The default mode network and rumination in individuals at risk for depression | journal = Social Cognitive and Affective Neuroscience | volume = 18 | issue = 1 | pages = nsad032 | date = June 2023 | pmid = 37261927 | pmc = 10634292 | doi = 10.1093/scan/nsad032 }}</ref> In studies done with single use psilocybin, areas of the DMN showed decreased functional connectivity (communication between areas of the brain). This provides functional insight into the work of psilocybin in increasing one's sense of connection to one's surroundings, as the areas of the brain involved in introspection decrease in functionality under the effects of the drug.<ref>{{cite journal | vauthors = Gattuso JJ, Perkins D, Ruffell S, Lawrence AJ, Hoyer D, Jacobson LH, Timmermann C, Castle D, Rossell SL, Downey LA, Pagni BA, Galvão-Coelho NL, Nutt D, Sarris J | title = Default Mode Network Modulation by Psychedelics: A Systematic Review | journal = The International Journal of Neuropsychopharmacology | volume = 26 | issue = 3 | pages = 155–188 | date = March 2023 | pmid = 36272145 | pmc = 10032309 | doi = 10.1093/ijnp/pyac074 | author-link9 = Susan Rossell }}</ref> Conversely, areas of the brain involved in the ToMN showed increased activity and functional activation in response to psychedelics. These results were not unique to psilocybin and there was no significant difference in brain activation found in similar trials of mescaline and LSD. Information and studies into the DMN and ToMN are relatively sparse and their connections to other psychiatric illnesses and the use of psychedelics is still largely unknown.<ref name=":0" />