Editing Protein phosphatase (section)

==Alternative Structural Classification==
Many phosphatases are promiscuous with respect to substrate type, or can evolve quickly to change substrate. An alternative structural classification<ref name="ChenManning">{{cite journal | vauthors = Chen MJ, Dixon JE, Manning G | title = Genomics and evolution of protein phosphatases | journal = Science Signaling | volume = 10 | issue = 474 | pages = eaag1796 | date = April 2017 | pmid = 28400531 | doi = 10.1126/scisignal.aag1796 | s2cid = 41041971 }}</ref> notes that 20 distinct protein folds have phosphatase activity, and 10 of these contain protein phosphatases.
* The CC1 fold is the most common, and includes tyrosine-specific (PTP), dual-specific (DSP) and even lipid-specific (PTEN) families.
* The major serine/threonine-specific folds are PPM (PP2C) and PPPL (PPP).
* The only known histidine phosphatases is in the PHP fold.
* Other folds encode phosphatases that act on various combination of pSer, pThr, pTyr, and non-protein substrates (CC2, [[protein tyrosine phosphatase#Class IV|CC3]], [[protein tyrosine phosphatase#Class IV|HAD]], HP, [[alkaline phosphatase|AP]], RTR1).