Editing Nitroglycerin (section)

== Industrial exposure ==
Infrequent exposure to high doses of nitroglycerin can cause severe [[headache]]s known as "NG head" or "bang head". These headaches can be severe enough to incapacitate some people; however, humans develop a [[tachyphylaxis|tolerance]] to and dependence on nitroglycerin after long-term exposure. Although rare, withdrawal can be fatal;<ref name="CDT">{{cite book|last1=Amdur |first1=Mary O. |last2=Doull |first2=John |title=Casarett and Doull's Toxicology |edition=4th |publisher=Elsevier |date=1991 |isbn=978-0071052399}}</ref> symptoms include chest pain and other heart problems.  These symptoms may be relieved with re-exposure to nitroglycerin or other suitable organic nitrates.<ref name="Jr.Krieger2001">{{cite book| first1=John B. Jr. |last1=Sullivan |first2=Gary R. |last2=Krieger|title=Clinical Environmental Health and Toxic Exposures: Latex|url=https://books.google.com/books?id=PyUSgdZUGr4C&pg=PA264|access-date=23 April 2013|year=2001|publisher=Lippincott Williams & Wilkins|isbn=978-0-683-08027-8|pages=264}}</ref>

For workers in nitroglycerin (NTG) manufacturing facilities, the effects of withdrawal sometimes include "Sunday heart attacks" in those experiencing regular nitroglycerin exposure in the workplace, leading to the development of tolerance for the venodilating effects. Over the weekend, the workers lose the tolerance, and when they are re-exposed on Monday, the drastic [[vasodilation]] produces a [[tachycardia|fast heart rate]], dizziness, and a headache. This is referred to as "Monday disease."<ref name="Short history">{{cite journal |last1=Marsh |first1=N. |last2=Marsh |first2=A. |title=A short history of nitroglycerine and nitric oxide in pharmacology and physiology |journal=Clinical and Experimental Pharmacology and Physiology |volume=27 |issue=4 |pages=313–319 |year=2000 |pmid=10779131 |doi= 10.1046/j.1440-1681.2000.03240.x|s2cid=12897126 }}</ref><ref name="Toxicology">{{cite book|author=Assembly of Life Sciences (U.S.) Advisory Center on Toxicology|title=Toxicological Reports|url=https://books.google.com/books?id=fEQrAAAAYAAJ&pg=PA115|access-date=23 April 2013|publisher=National Academies|pages=115|id=NAP:11288}}</ref>

People can be exposed to nitroglycerin in the workplace by breathing it in, skin absorption, swallowing it, or eye contact. The [[Occupational Safety and Health Administration]]  has set the legal limit ([[permissible exposure limit]]) for nitroglycerin exposure in the workplace as 0.2&nbsp;ppm (2&nbsp;mg/m<sup>3</sup>) skin exposure over an 8-hour workday. The [[National Institute for Occupational Safety and Health]]  has set a [[recommended exposure limit]]  of 0.1&nbsp;mg/m<sup>3</sup> skin exposure over an 8-hour workday. At levels of 75&nbsp;mg/m<sup>3</sup>, nitroglycerin is [[IDLH|immediately dangerous to life and health]].<ref>{{Cite web|publisher= CDC |work=NIOSH Pocket Guide to Chemical Hazards |title=Nitroglycerine|url = https://www.cdc.gov/niosh/npg/npgd0456.html|access-date = 2015-11-21}}</ref>