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====Children==== Naloxone can be used on infants who were exposed to intrauterine opiates administered to mothers during delivery. However, there is insufficient evidence for the use of naloxone to lower cardiorespiratory and neurological depression in these infants.<ref name="Naloxone for opioid-exposed newborn">{{cite journal | vauthors = Moe-Byrne T, Brown JV, McGuire W | title = Naloxone for opioid-exposed newborn infants | journal = The Cochrane Database of Systematic Reviews | volume = 2018 | issue = 10 | pages = CD003483 | date = October 2018 | pmid = 30311212 | pmc = 6517169 | doi = 10.1002/14651858.CD003483.pub3 }}</ref> Infants exposed to high concentrations of opiates during pregnancy may have CNS damage in the setting of [[perinatal asphyxia]]. Naloxone has been studied to improve outcomes in this population, however the evidence is currently weak.<ref>{{cite journal | vauthors = McGuire W, Fowlie PW, Evans DJ | title = Naloxone for preventing morbidity and mortality in newborn infants of greater than 34 weeks gestation with suspected perinatal asphyxia | journal = The Cochrane Database of Systematic Reviews | issue = 1 | pages = CD003955 | date = 26 January 2004 | volume = 2010 | pmid = 14974047 | pmc = 6485479 | doi = 10.1002/14651858.CD003955.pub2 | publisher = John Wiley & Sons, Ltd }}</ref><ref name="Naloxone for opioid-exposed newborn"/> Intravenous, intramuscular, or subcutaneous administration of naloxone can be given to children and neonates to reverse opiate effects. The [[American Academy of Pediatrics]] recommends only intravenous administration as the other two forms can cause unpredictable absorption. After a dose is given, the child should be monitored for at least 24 hours. For children with low blood pressure due to [[septic shock]], naloxone safety and effectiveness are not established.<ref>{{cite web|url=https://www.rxlist.com/narcan-drug.htm|title=Narcan (Naloxone Hydrochloride Injection): Side Effects, Interactions, Warning, Dosage & Uses|website=RxList|access-date=24 October 2019|archive-date=11 November 2020|archive-url=https://web.archive.org/web/20201111191403/https://www.rxlist.com/narcan-drug.htm|url-status=live}}</ref>
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