Editing Madison County, Florida (section)

===Major highways===
{{See also|List of county roads in Madison County, Florida}}
* {{jct|I|10|state=FL|name1=Interstate 10 / [[Florida State Road 8|SR 8]]}} is the main interstate highway through Madison County, running west and east through the panhandle from Alabama to Jacksonville. Four interchanges exist in the county at US 221 south of Greenville, (Exit 241), SR 14 (Exit 251) and SR 53 (Exit 258) south of Madison, and CR 255 south of Lee (Exit 262).
* {{jct|US|19|US|27|state=FL|name2=[[Florida State Road 20|SR 20]]}} is a multiplexed pair of south-to-north US highways that briefly runs through the southwestern corner of the county known as the [[Florida-Georgia Parkway]].
* {{jct|US|90|state=FL|name1=[[Florida State Road 10|SR 10]]}} was the main west-to-east route through Madison County until it was supplanted by I-10.
* {{jct|US|221|state=FL|name1=[[Florida State Road 55|SR 55]]}} is the main south-to-north US highway in western Madison County.
* {{jct|FL|6|state=FL}} runs northeast from US 90 into Jasper in Hamilton County east of Madison.
* {{jct|FL|14|state=FL}} is a short state road from I-10 to US 90 in Madison, with a western county extension in Taylor and Madison Counties, and a truck route to SR 53 (''see below'').
* {{jct|FL|53|state=FL}} is a south-to-north state road that runs from I-10 at exit 251 through Madison, and eventually the Georgia State Line. It also has a southern bi-county extension that runs through Day, Florida, and Buckville, Florida in Lafayette County at US 27.
* {{jct|FL|145|state=FL}}, a south-to-north state road in northeastern Madison County The route begins at the eastern terminus of the US 90/SR 53 overlap in Madison, then turns to the northeast towards Valdosta, across the Georgia State Line.