Editing Macrolide (section)

==Examples==
===Antibiotic macrolides===
US FDA-approved:
*[[Azithromycin]]{{snd}} unique; does not extensively inhibit [[CYP3A4]]<ref name="pmid31628882"/>
*[[Clarithromycin]]
*[[Dirithromycin]]{{snd}} discontinued but was US FDA approved
*[[Erythromycin]]

[[File:Azithromycin 250mg.jpg|thumb|[[Azithromycin]] capsules]]
Not approved in the US by FDA but approved in the other countries by respective national authorities:
*[[Carbomycin|Carbomycin A]]
*[[Josamycin]]
*[[Kitasamycin]]
*[[Midecamycin]]/[[midecamycin acetate]]
*[[Oleandomycin]]
*[[Spiramycin]]{{snd}} approved in the EU, and in other countries
*[[Troleandomycin]]{{snd}} used in Italy and Turkey
*[[Tylosin]]/[[tylocine]]{{snd}} used in animals
*[[Roxithromycin]]

Not approved as a drug for medical use:
*[[Boromycin]] (not a member of the classical 14&ndash;16-membered class)<ref name="pmid17991498">{{cite journal | vauthors = Rezanka T, Sigler K | title = Biologically active compounds of semi-metals | journal = Phytochemistry | volume = 69 | issue = 3 | pages = 585–606 | date = February 2008 | pmid = 17991498 | doi = 10.1016/j.phytochem.2007.09.018 | bibcode = 2008PChem..69..585R }}</ref>

===Ketolides===
[[Ketolide]]s are a class of antibiotics that are structurally related to the macrolides. They are used to treat respiratory tract infections caused by macrolide-resistant bacteria. Ketolides are especially effective, as they have two ribosomal binding sites.

Ketolides include:
*[[Telithromycin]]{{snd}} the first and only approved ketolide<ref>{{cite journal | vauthors = Nguyen M, Chung EP | title = Telithromycin: the first ketolide antimicrobial | journal = Clinical Therapeutics | volume = 27 | issue = 8 | pages = 1144–63 | date = August 2005 | pmid = 16199242 | doi = 10.1016/j.clinthera.2005.08.009 }}</ref>
*[[Cethromycin]]
*[[Solithromycin]]

===Fluoroketolides===
Fluoroketolides are a class of antibiotics that are structurally related to the ketolides. The fluoroketolides have three ribosomal interaction sites.

Fluoroketolides include:
*[[Solithromycin]]{{snd}} the first and so far only fluoroketolide (not yet approved)

===Non-antibiotic macrolides===
The drugs [[tacrolimus]], [[pimecrolimus]], and [[sirolimus]], which are used as [[immunosuppressant]]s or immunomodulators, are also macrolides. They have similar activity to [[ciclosporin]].

===Antifungal drugs===
[[Polyene antimycotic]]s, such as [[amphotericin B]], [[nystatin]] etc., are a subgroup of macrolides.<ref>{{cite journal | vauthors = Hamilton-Miller JM | title = Chemistry and biology of the polyene macrolide antibiotics | journal = Bacteriological Reviews | volume = 37 | issue = 2 | pages = 166–96 | date = June 1973 | doi = 10.1128/br.37.3.166-196.1973 | pmid = 4578757 | pmc = 413810 }}</ref> [[Cruentaren]] is another example of an antifungal macrolide.<ref>{{cite journal | vauthors = Kunze B, Sasse F, Wieczorek H, Huss M | title = Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases | journal = FEBS Letters | volume = 581 | issue = 18 | pages = 3523–7 | date = July 2007 | pmid = 17624334 | doi = 10.1016/j.febslet.2007.06.069 | doi-access = free | bibcode = 2007FEBSL.581.3523K }}</ref>

===Toxic macrolides===
A variety of toxic macrolides produced by bacteria have been isolated and characterized, such as the [[mycolactone]]s.