Editing Lymphoma (section)

====Previous classifications====

Several previous classifications have been used, including Rappaport 1956, Lennert/Kiel 1974, BNLI, Working formulation (1982), and REAL (1994).

The [[Working Formulation]] of 1982 was a classification of [[non-Hodgkin lymphoma]]. It excluded the Hodgkin lymphomas and divided the remaining lymphomas into four grades (low, intermediate, high, and miscellaneous) related to prognosis, with some further subdivisions based on the size and shape of affected cells. This purely histological classification included no information about [[cell surface markers]] or genetics and made no distinction between [[T-cell lymphoma]]s and [[B-cell lymphoma]]s. It was widely accepted at the time of its publication but by 2004 was obsolete.<ref>{{cite journal | vauthors = Clarke CA, Glaser SL, Dorfman RF, Bracci PM, Eberle E, Holly EA | title = Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 13 | issue = 1 | pages = 138–143 | date = January 2004 | pmid = 14744745 | doi = 10.1158/1055-9965.EPI-03-0250 | doi-access = free }}</ref>

In 1994, the Revised European-American Lymphoma (REAL) classification applied immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas except Hodgkin lymphoma.<ref>{{EMedicine|article|203399|Non-Hodgkin Lymphoma}}</ref> For coding purposes, the [[ICD-O]] (codes 9590–9999)<ref>{{cite web|url=http://www.cog.ufl.edu/publ/apps/icdo/icdo_morph.txt |title=Archived copy |access-date=2005-11-07 |url-status=bot: unknown |archive-url=https://web.archive.org/web/20040627090029/http://www.cog.ufl.edu/publ/apps/icdo/icdo_morph.txt |archive-date=June 27, 2004 }}</ref> and [[ICD|ICD-10]] (codes C81-C96)<ref>{{Cite web|title=2022 ICD-10-CM Codes C81-C96: Malignant neoplasms of lymphoid, hematopoietic and related tissue|url=https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96|access-date=2022-02-02|website=www.icd10data.com|archive-date=2022-01-17|archive-url=https://web.archive.org/web/20220117013750/https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96|url-status=live}}</ref> are available.