Editing Golgi apparatus (section)

===Model 2: Cisternal progression/maturation===
* In this model, the fusion of COPII vesicles from the ER begins the formation of the first ''cis''-cisterna of the Golgi stack, which progresses later to become mature TGN cisternae. Once matured, the TGN cisternae dissolve to become secretory vesicles. While this progression occurs, COPI vesicles continually recycle Golgi-specific proteins by delivery from older to younger cisternae. Different recycling patterns may account for the differing biochemistry throughout the Golgi stack. Thus, the compartments within the Golgi are seen as discrete kinetic stages of the maturing Golgi apparatus.<ref name="Glick-2011"/>
** '''Strengths:''' The model addresses the existence of Golgi compartments, as well as differing biochemistry within the cisternae, transport of large proteins, transient formation and disintegration of the cisternae, and retrograde mobility of native Golgi proteins, and it can account for the variability seen in the structures of the Golgi.<ref name="Glick-2011"/>
** '''Weaknesses:''' This model cannot easily explain the observation of fused Golgi networks, tubular connections among cisternae, and differing kinetics of secretory cargo exit.<ref name="Glick-2011"/>