Editing Epicanthic fold (section)

== Other factors ==
[[File:Bosquimanos-Grassland Bushmen Lodge, Botswana 03.jpg|thumb|The [[Khoi]], the [[San people|San]] and some other African groups have a high frequency of the epicanthic fold.]]

=== Age ===
Many [[fetus]]es lose their epicanthic folds after three to six months of gestation.<ref>{{Cite journal |last=Park JI |date=1 January 2000 |title=Modified Z-Epicanthoplasty in the Asian Eyelid |url=http://archfaci.jamanetwork.com/article.aspx?articleid=479760 |journal=Archives of Facial Plastic Surgery |volume=2 |issue=1 |pages=43–47 |issn=1521-2491 |doi=10.1001/archfaci.2.1.43 |pmid=10925423}}</ref> Epicanthic folds may be visible in the development stages of young children of any ethnicity, especially before the nose bridge fully develops.<ref>{{cite web |title=Epicanthal folds |url=https://medlineplus.gov/ency/article/003030.htm |website=MedlinePlus |publisher=U.S National Library of Medicine}}</ref>

=== Medical conditions ===
Epicanthic fold prevalence can sometimes be found as a sign of congenital abnormality, such as in [[Zellweger syndrome]]<ref>{{cite journal |last1=Kalyanasundaram |first1=S. |first2=Samuel E. |last2=Ibhanesebhor |first3=Chikkanayakanahalli M. |last3=Manjunatha |year=2010 |display-authors=1 |title=Peroxisomal Disorder-Unusual Presentation as Failure to Thrive in Early Infancy |journal=Indian Journal of Pediatrics |volume=77 |issue=10 |pages=1151–1152 |doi=10.1007/s12098-010-0199-6 |pmid=20872098 |s2cid=5736554 }}</ref> and [[Noonan syndrome]]. Medical conditions that cause the nasal bridge not to develop and project are also associated with epicanthic fold. About 60% of individuals with [[Down syndrome]] (also known as trisomy 21) have prominent epicanthic folds.<ref name=Steph2010>{{cite book |last1=Hammer |first1=Gary, D. |last2=McPhee |first2=Stephen J. |title=Pathophysiology of Disease: An Introduction to Clinical Medicine |year=2010 |publisher=McGraw-Hill Medical |location=New York |isbn=978-0-07-162167-0 |edition=6 |chapter=Pathophysiology of Selected Genetic Diseases}}</ref><ref>Pham, V. (2010). COMMON OTOLARYNGOLOGICAL CONGENITAL ABNORMALITIES. UTMB, Dept. of Otolaryngology. [http://www.utmb.edu/otoref/grnds/congenital-abnormal-101122/congen-abnom-101122.pdf] {{Webarchive|url=https://web.archive.org/web/20111006044747/http://www.utmb.edu/otoref/Grnds/congenital-abnormal-101122/congen-abnom-101122.pdf|date=6 October 2011}}</ref>

Other examples are [[fetal alcohol syndrome]], [[phenylketonuria]], and [[Turner syndrome]].<ref>{{cite web|url=https://medlineplus.gov/ency/article/003030.htm |title=Epicanthal folds |first1=Neil K. |last1=Kaneshiro |first2=David |last2=Zieve |first3=Isla |last3=Ogilvie |work=[[MedlinePlus]]}}</ref>[[File:Epicanthic KR07.jpg|thumb|Epicanthic folds ('''Note that the tarsal plates are exposed Laterally.''')]]