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Diabetic ketoacidosis
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===Criteria=== Diabetic ketoacidosis is distinguished from other diabetic emergencies by the presence of large amounts of ketones in blood and urine, and marked metabolic acidosis. [[Nonketotic hyperosmolar coma|Hyperosmolar hyperglycemic state]] (HHS, sometimes labeled "hyperosmolar non-ketotic state" or HONK) is much more common in type 2 diabetes and features increased [[plasma osmolarity]] (above 320 mosm/kg) due to profound dehydration and concentration of the blood; mild acidosis and ketonemia may occur in this state, but not to the extent observed in DKA. There is a degree of overlap between DKA and HHS, as in DKA the osmolarity may also be increased.<ref name=ADA2009/> [[Ketoacidosis]] is not always the result of diabetes. It may also result from [[alcoholic beverage|alcohol excess]] and from [[starvation]]; in both states the glucose level is normal or low. [[Metabolic acidosis]] may occur in people with diabetes for other reasons, such as [[poison]]ing with [[ethylene glycol]] or [[paraldehyde]].<ref name=ADA2009/> The [[American Diabetes Association]] categorizes DKA in adults into one of three stages of severity:<ref name=ADA2009/> * ''Mild:'' blood pH mildly decreased to between 7.25 and 7.30 (normal 7.35β7.45); serum [[bicarbonate]] decreased to 15β18 mmol/L (normal above 20); the person is alert * ''Moderate:'' pH 7.00β7.25, bicarbonate 10β15, mild drowsiness may be present * ''Severe:'' pH below 7.00, bicarbonate below 10, stupor or coma may occur A 2004 statement by the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society (for children) uses slightly different cutoffs, where mild DKA is defined by pH 7.20β7.30 (bicarbonate 10β15 mmol/L), moderate DKA by pH 7.1β7.2 (bicarbonate 5β10) and severe DKA by pH<7.1 (bicarbonate below 5).<ref name=ESPE/>
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