Editing Cowpox (section)

===Kinepox===
Kinepox is an alternative term for the [[smallpox vaccine]] used in early 19th-century America. Popularized by Jenner in the late 1790s, kinepox was a far safer method for inoculating people against smallpox than the previous method, [[variolation]], which had a 3% fatality rate.{{citation needed|date=October 2021}}

In a famous letter to [[Meriwether Lewis]] in 1803, [[Thomas Jefferson]] instructed the [[Lewis and Clark Expedition]] to "carry with you some matter of the kine-pox; inform those of them with whom you may be, of its efficacy as a preservative from the smallpox; & encourage them in the use of it..."<ref>{{cite web | url = http://www.library.csi.cuny.edu/dept/history/lavender/jefflett.html | title = Jefferson's Instructions to Lewis and Clark (1803) | access-date = 2007-08-10 | url-status = dead | archive-url = https://web.archive.org/web/20070807100953/http://www.library.csi.cuny.edu/dept/history/lavender/jefflett.html | archive-date = 2007-08-07 }}</ref> Jefferson had developed an interest in protecting [[Indigenous peoples of the Americas|American Indians]] from smallpox, having been aware of [[epidemic]]s along the [[Missouri River]] during the previous century. A year before his special instructions to Lewis, Jefferson had persuaded a visiting [[delegation]] of North American Indian chieftains to be vaccinated with kinepox during the winter of 1801–1802. Unfortunately, Lewis never got the opportunity to use kinepox during the pair's expedition, as it had become inadvertently inactive—a common occurrence in a time before vaccines were [[stabilizer (chemistry)|stabilized]] with [[preservatives]] such as [[glycerol]] or kept at refrigeration temperatures.{{citation needed|date=November 2022}}