Editing Chelation (section)

=== Nutritional advantages and issues ===
Chelation in the intestinal tract is a cause of numerous interactions between drugs and metal ions (also known as "[[Dietary mineral|minerals]]" in nutrition). As examples, [[antibiotic]] [[medication|drug]]s of the [[tetracycline]] and [[Quinolone antibiotic|quinolone]] families are chelators of [[iron|Fe]]<sup>2+</sup>, [[Calcium|Ca]]<sup>2+</sup>, and [[Magnesium|Mg]]<sup>2+</sup> ions.<ref>{{cite journal |vauthors=Campbell NR, Hasinoff BB |title=Iron supplements: a common cause of drug interactions |journal=British Journal of Clinical Pharmacology |volume=31 |issue=3 |pages=251–5 |date=March 1991 |pmid=2054263 |pmc=1368348 |doi=10.1111/j.1365-2125.1991.tb05525.x}}</ref><ref>{{cite journal |vauthors=Lomaestro BM, Bailie GR |title=Absorption interactions with fluoroquinolones. 1995 update |journal=Drug Safety |volume=12 |issue=5 |pages=314–33 |date=May 1995 |pmid=7669261 |doi=10.2165/00002018-199512050-00004 |s2cid=2006138}}</ref>

EDTA, which binds to calcium, is used to alleviate the [[hypercalcemia]] that often results from [[band keratopathy]].  The calcium may then be removed from the [[cornea]], allowing for some increase in clarity of vision for the patient.<ref>{{Cite journal |last=Najjar |first=Dany M. |last2=Cohen |first2=Elisabeth J. |last3=Rapuano |first3=Christopher J. |last4=Laibson |first4=Peter R. |date=June 2004 |title=EDTA chelation for calcific band keratopathy: results and long-term follow-up |url=https://pubmed.ncbi.nlm.nih.gov/15183790/ |journal=American Journal of Ophthalmology |volume=137 |issue=6 |pages=1056–1064 |doi=10.1016/j.ajo.2004.01.036 |issn=0002-9394 |pmid=15183790}}</ref><ref>{{Cite journal |last=Al-Hity |first=A |last2=Ramaesh |first2=K |last3=Lockington |first3=D |date=December 1, 2017 |title=EDTA chelation for symptomatic band keratopathy: results and recurrence |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC5770724/ |journal=Eye |language=en |volume=32 |issue=1 |pages=26–31 |doi=10.1038/eye.2017.264 |issn=0950-222X |archive-url=http://web.archive.org/web/20250202182230/https://pmc.ncbi.nlm.nih.gov/articles/PMC5770724/ |archive-date=February 2, 2025|pmc=5770724}}</ref>

[[Homogeneous catalyst]]s are often chelated complexes. A representative example is the use of [[BINAP]] (a bidentate [[phosphine]]) in [[Noyori asymmetric hydrogenation]] and asymmetric isomerization. The latter has the practical use of manufacture of synthetic [[Menthol|(–)-menthol]].