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===Acute health effects=== Capsaicin is a strong irritant requiring proper protective goggles, respirators, and proper hazardous material-handling procedures. Capsaicin takes effect upon skin contact (irritant, sensitizer), eye contact (irritant), ingestion, and inhalation (lung irritant, lung sensitizer). The {{LD50}} in mice is 47.2 mg/kg.<ref name="tox">{{cite web |url=http://www.sciencelab.com/xMSDS-Capsaicin_Natural-9923296 |title=Capsaicin Material Safety Data Sheet |access-date=13 July 2007 |publisher=sciencelab.com |year=2007 |format=PDF |archive-url=https://web.archive.org/web/20070929083820/http://www.sciencelab.com/xMSDS-Capsaicin_Natural-9923296 |archive-date=29 September 2007 |url-status=dead }}</ref><ref name="pmid17365137">{{cite journal | vauthors = Johnson W | title = Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin | journal = International Journal of Toxicology | volume = 26 | issue = Suppl 1 | pages = 3β106 | year = 2007 | pmid = 17365137 | doi = 10.1080/10915810601163939 | s2cid = 208154058 | doi-access = free}}</ref> Painful exposures to capsaicin-containing peppers are among the most common plant-related exposures presented to poison centers.<ref>{{cite journal | vauthors = Krenzelok EP, Jacobsen TD | title = Plant exposures ... a national profile of the most common plant genera | journal = Veterinary and Human Toxicology | volume = 39 | issue = 4 | pages = 248β249 | date = August 1997 | pmid = 9251180}}</ref> They cause burning or stinging pain to the skin and, if ingested in large amounts by adults or small amounts by children, can produce nausea, vomiting, abdominal pain, and burning diarrhea. Eye exposure produces intense tearing, pain, [[conjunctivitis]], and [[blepharospasm]].<ref name="tox2">{{Cite book|title=Goldfrank's Toxicologic Emergencies | veditors = Goldfrank LR |page=1167 |publisher=McGraw-Hill |location=New York, New York|isbn=978-0-07-144310-4|date=23 March 2007 }}</ref>
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