Editing Bioinformatics (section)

==== Gene function prediction ====
While genome annotation is primarily based on sequence similarity (and thus [[Homology (biology)|homology]]), other properties of sequences can be used to predict the function of genes. In fact, most ''gene'' function prediction methods focus on ''protein'' sequences as they are more informative and more feature-rich. For instance, the distribution of hydrophobic [[amino acid]]s predicts [[Transmembrane domain|transmembrane segments]] in proteins. However, protein function prediction can also use external information such as gene (or protein) [[Gene expression|expression]] data, [[protein structure]], or [[protein-protein interactions]].<ref>{{cite journal |vauthors=Erdin S, Lisewski AM, Lichtarge O |title=Protein function prediction: towards integration of similarity metrics |journal=Current Opinion in Structural Biology |volume=21 |issue=2 |pages=180–8 |date=April 2011 |pmid=21353529 |pmc=3120633 |doi=10.1016/j.sbi.2011.02.001}}</ref>