Editing Biochemistry (section)

==Metabolism==

===Carbohydrates as energy source===
{{Main|Carbohydrate metabolism|Carbon cycle}}
Glucose is an energy source in most life forms. For instance, polysaccharides are broken down into their monomers by [[enzyme]]s ([[glycogen phosphorylase]] removes glucose residues from glycogen, a polysaccharide). Disaccharides like lactose or sucrose are cleaved into their two component monosaccharides.<ref>{{cite web |title=Disaccharide |url=https://www.britannica.com/science/disaccharide |access-date=14 October 2023 |website=Encyclopedia Britannica |archive-date=19 October 2023 |archive-url=https://web.archive.org/web/20231019212527/https://www.britannica.com/science/disaccharide |url-status=live }}</ref>

====Glycolysis (anaerobic)====
{{Glycolysis summary}}
Glucose is mainly metabolized by a very important ten-step [[Metabolic pathway|pathway]] called [[glycolysis]], the net result of which is to break down one molecule of glucose into two molecules of [[pyruvate]]. This also produces a net two molecules of [[Adenosine triphosphate|ATP]], the energy currency of cells, along with two reducing equivalents of converting [[Nicotinamide adenine dinucleotide|NAD<sup>+</sup>]] (nicotinamide adenine dinucleotide: oxidized form) to NADH (nicotinamide adenine dinucleotide: reduced form). This does not require oxygen; if no oxygen is available (or the cell cannot use oxygen), the NAD is restored by converting the pyruvate to [[lactic acid|lactate (lactic acid)]] (e.g. in humans) or to [[ethanol]] plus carbon dioxide (e.g. in [[yeast]]). Other monosaccharides like galactose and fructose can be converted into intermediates of the glycolytic pathway.<ref>[[#Fromm|Fromm and Hargrove]] (2012), pp. 163–180.</ref>

====Aerobic====
In [[aerobic glycolysis|aerobic]] cells with sufficient [[oxygen]], as in most human cells, the pyruvate is further metabolized. It is irreversibly converted to [[acetyl-CoA]], giving off one carbon atom as the waste product [[carbon dioxide]], generating another reducing equivalent as [[NADH]]. The two molecules acetyl-CoA (from one molecule of glucose) then enter the [[citric acid cycle]], producing two molecules of ATP, six more NADH molecules and two reduced (ubi)quinones (via [[FADH2|FADH<sub>2</sub>]] as enzyme-bound cofactor), and releasing the remaining carbon atoms as carbon dioxide. The produced NADH and quinol molecules then feed into the enzyme complexes of the respiratory chain, an [[electron transport system]] transferring the electrons ultimately to oxygen and conserving the released energy in the form of a proton gradient over a membrane ([[inner mitochondrial membrane]] in eukaryotes). Thus, oxygen is reduced to water and the original electron acceptors NAD<sup>+</sup> and [[quinone]] are regenerated. This is why humans breathe in oxygen and breathe out carbon dioxide. The energy released from transferring the electrons from high-energy states in NADH and quinol is conserved first as proton gradient and converted to ATP via ATP synthase. This generates an additional ''28'' molecules of ATP (24 from the 8 NADH + 4 from the 2 quinols), totaling to 32 molecules of ATP conserved per degraded glucose (two from glycolysis + two from the citrate cycle).<ref>[[#Voet|Voet]] (2005), Ch. 17 Glycolysis.</ref> It is clear that using oxygen to completely oxidize glucose provides an organism with far more energy than any oxygen-independent metabolic feature, and this is thought to be the reason why complex life appeared only after Earth's atmosphere accumulated large amounts of oxygen.

====Gluconeogenesis====
{{Main|Gluconeogenesis}}
In [[vertebrate]]s, vigorously contracting [[skeletal muscle]]s (during weightlifting or sprinting, for example) do not receive enough oxygen to meet the energy demand, and so they shift to [[Fermentation (biochemistry)|anaerobic metabolism]], converting glucose to lactate.
The combination of glucose from noncarbohydrates origin, such as fat and proteins. This only happens when [[glycogen]] supplies in the liver are worn out. The pathway is a crucial reversal of [[glycolysis]] from pyruvate to glucose and can use many sources like amino acids, glycerol and [[Krebs Cycle]]. Large scale protein and fat [[catabolism]] usually occur when those suffer from starvation or certain endocrine disorders.<ref>{{Cite book| url=https://www.oxfordreference.com/view/10.1093/acref/9780198714378.001.0001/acref-9780198714378| isbn=9780198714378| title=A Dictionary of Biology| date=17 September 2015| publisher=Oxford University Press| access-date=29 April 2020| archive-date=10 July 2020| archive-url=https://web.archive.org/web/20200710005409/https://www.oxfordreference.com/view/10.1093/acref/9780198714378.001.0001/acref-9780198714378| url-status=live}}</ref> The [[liver]] regenerates the glucose, using a process called [[gluconeogenesis]]. This process is not quite the opposite of glycolysis, and actually requires three times the amount of energy gained from glycolysis (six molecules of ATP are used, compared to the two gained in glycolysis). Analogous to the above reactions, the glucose produced can then undergo glycolysis in tissues that need energy, be stored as glycogen (or [[starch]] in plants), or be converted to other monosaccharides or joined into di- or oligosaccharides. The combined pathways of glycolysis during exercise, lactate's crossing via the bloodstream to the liver, subsequent gluconeogenesis and release of glucose into the bloodstream is called the [[Cori cycle]].<ref>[[#Fromm|Fromm and Hargrove]] (2012), pp. 183–194.</ref>