Editing Axon (section)

===Axon terminals===
{{Main|Axon terminal}}
An axon can divide into many branches called telodendria (Greek for 'end of tree'). At the end of each '''telodendron''' is an [[axon terminal]] (also called a terminal bouton or synaptic bouton, or [[Wikt:end-foot|end-foot]]).<ref name="MW">{{cite web |title=Medical Definition of bouton |url=https://www.merriam-webster.com/medical/bouton |website=www.merriam-webster.com |access-date=21 September 2024 |language=en}}</ref> Axon terminals contain [[synaptic vesicle]]s that store the [[neurotransmitter]] for release at the [[Chemical synapse|synapse]]. This makes multiple synaptic connections with other neurons possible. Sometimes the axon of a neuron may synapse onto dendrites of the same neuron, when it is known as an [[autapse]]. Some synaptic junctions appear along the length of an axon as it extends; these are called '''en passant boutons''' ("in passing boutons") and can be in the hundreds or even the thousands along one axon.<ref name="LS">{{cite book|last1=Squire|first1=Larry|title=Fundamental neuroscience|date=2013|publisher=Elsevier/Academic Press|location=Amsterdam|isbn=978-0-12-385-870-2|pages=61–65|edition=4th}}</ref>

====Axonal varicosities====
In the normally developed brain, along the shaft of some axons are located pre-synaptic boutons also known as '''axonal varicosities''' and these have been found in regions of the [[hippocampus]] that function in the release of neurotransmitters.<ref name="Gu">{{cite journal |vauthors=Gu C |title=Rapid and Reversible Development of Axonal Varicosities: A New Form of Neural Plasticity |journal=Front Mol Neurosci |volume=14 |issue= |pages=610857 |date=2021 |pmid=33613192 |pmc=7886671 |doi=10.3389/fnmol.2021.610857 |url= |doi-access=free }}</ref> However, axonal varicosities are also present in neurodegenerative diseases where they interfere with the conduction of an action potential. Axonal varicosities are also the hallmark of [[traumatic brain injuries]].<ref name="Gu"/><ref name="Weber">{{cite journal |vauthors=Weber MT, Arena JD, Xiao R, Wolf JA, Johnson VE |title=CLARITY reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury |journal=Brain Pathol |volume=29 |issue=3 |pages=437–450 |date=May 2019 |pmid=30444552 |pmc=6482960 |doi=10.1111/bpa.12677 |url=}}</ref> Axonal damage is usually to the axon  cytoskeleton disrupting transport. As a consequence protein accumulations such as [[amyloid-beta precursor protein]] can build up in a swelling resulting in a number of varicosities along the axon.<ref name="Gu"/><ref name="Weber"/>